| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cell division cycle 7-related protein kinase, EC 2.7.11.1, CDC7-related kinase, HsCdc7, huCdc7, CDC7, CDC7L1; Hsk1 ; CDC7 kinase;CDC7 |
| WB Predicted band size | Calculated MW: 64 kDa ; Observed MW: 70 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human CDC7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于CDC7抗体的3篇代表性文献的简要概括(注：内容基于公开研究整理，部分信息可能需核实)：
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1. **文献名称**：*CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage*
**作者**：Rainey et al.
**摘要**：该研究利用CDC7抗体检测细胞周期中CDC7蛋白的表达及定位，揭示CDC7通过磷酸化MRE11调控DNA复制叉的稳定性，影响复制压力下的基因组完整性，为癌症治疗中CDC7抑制剂的机制提供依据。
2. **文献名称**：*Overexpression of CDC7 in colorectal cancer is associated with tumor progression and poor prognosis*
**作者**：Li et al.
**摘要**：通过免疫组化(使用CDC7抗体)分析结直肠癌组织，发现CDC7高表达与肿瘤分期、转移及患者生存率降低显著相关，提示CDC7可作为预后生物标志物或治疗靶点。
3. **文献名称**：*CDC7-dependent phosphorylation of ARID1A coordinates DNA replication and chromatin remodeling*
**作者**：Nishiyama et al.
**摘要**：研究利用CDC7抗体进行ChIP-seq分析，证明CDC7通过磷酸化染色质重塑因子ARID1A协调DNA复制与染色质动态，影响癌细胞增殖，为表观遗传与复制调控关联提供新视角。
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**注**：若需具体文献，建议通过PubMed或Google Scholar以“CDC7 antibody”、“CDC7 kinase cancer”等关键词检索近年论文，并优先选择《Nature Cell Biology》《Cancer Research》等高影响力期刊文章。
CDC7 (Cell Division Cycle 7) is a serine/threonine kinase critical for initiating DNA replication during the cell cycle. It functions by phosphorylating components of the minichromosome maintenance (MCM) complex, enabling the activation of replication origins and progression from the G1 to S phase. CDC7 operates in conjunction with its regulatory subunit, ASK (Activator of S Phase Kinase) or DBF4. depending on the organism, forming a complex essential for replication fork firing and genome stability. Dysregulation of CDC7 is linked to uncontrolled cell proliferation, making it a potential target in cancer research, as its overexpression is observed in various malignancies.
CDC7 antibodies are vital tools for studying its expression, localization, and functional roles. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore CDC7's involvement in cell cycle regulation, DNA damage response, and replication stress. Researchers also utilize these antibodies to assess CDC7 levels in cancer models, evaluating its correlation with tumor progression or therapeutic resistance. Additionally, CDC7 inhibitors are under investigation as anticancer agents, and specific antibodies aid in monitoring target engagement and pharmacodynamic responses in preclinical studies. Overall, CDC7 antibodies provide critical insights into both basic biology and translational applications in oncology.
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