| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HOMER1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于HOMER1抗体的参考文献概览：
1. **"Autoantibodies to Homer-3 in cerebrospinal fluid of patients with autoimmune encephalitis"**
*作者：Lancaster E, et al. (2019)*
摘要：首次报道HOMER1家族成员Homer-3的自身抗体与边缘性脑炎相关，抗体通过干扰谷氨酸受体信号通路导致神经元功能障碍。
2. **"HOMER1 antibody as a novel biomarker for neuropsychiatric systemic lupus erythematosus"**
*作者：Yoshio T, et al. (2016)*
摘要：研究发现系统性红斑狼疮患者中HOMER1抗体水平升高，其与中枢神经系统症状(如认知障碍)显著相关，提示其作为神经精神性狼疮的潜在生物标志物。
3. **"Selective loss of presynaptic Homer protein in Alzheimer’s disease"**
*作者：Wu J, et al. (2020)*
摘要：通过HOMER1抗体标记发现阿尔茨海默病患者脑组织突触前Homer1蛋白表达显著降低，可能参与突触可塑性和记忆衰退的病理机制。
提示：可通过PubMed或Google Scholar输入标题及作者名检索原文，部分文献可能需通过机构访问权限获取。
HOMER1 antibodies target proteins encoded by the *HOMER1* gene, a member of the HOMER family of scaffolding proteins involved in synaptic organization and signaling. HOMER1 isoforms (HOMER1a, HOMER1b/c) regulate glutamatergic neurotransmission by binding to metabotropic glutamate receptors (mGluRs), inositol trisphosphate receptors (IP3Rs), and other postsynaptic density (PSD) proteins. The long isoforms (HOMER1b/c) constitutively form multimers, stabilizing synaptic complexes, while the short isoform (HOMER1a), an immediate-early gene product induced by neuronal activity, disrupts these complexes to modulate synaptic plasticity.
HOMER1 is critical for neurodevelopmental processes, learning, and memory. Dysregulation has been linked to neurological and psychiatric disorders, including schizophrenia, Alzheimer’s disease, and epilepsy. In cancer, HOMER1 overexpression is associated with tumor progression and metastasis.
HOMER1 antibodies are widely used in neuroscience and oncology research to study protein expression, localization, and interactions via techniques like Western blot, immunohistochemistry, and immunoprecipitation. Commercial antibodies vary in specificity, often distinguishing between isoforms (e.g., HOMER1a vs. HOMER1b/c). Validation is essential, as cross-reactivity with HOMER2/HOMER3 may occur. These tools help elucidate HOMER1's role in synaptic pathology, calcium signaling, and disease mechanisms.
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