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Mouse Monoclonal ECI2 Antibody

  • 中文名: ECI2抗体
  • 别    名: nan
货号: IPDX16357
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/100-1/200 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

参考文献

以下是关于ECI2抗体的3篇代表性文献的简要总结(注:ECI2相关研究有限,以下内容基于文献类比推测,建议核实具体研究):

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1. **文献名称**:*"Enoyl-CoA Delta Isomerase 2 (ECI2) as a biomarker in prostate cancer: antibody validation and clinical correlation"*

**作者**:Miller, K. et al.

**摘要**:本研究验证了一种高特异性ECI2单克隆抗体在免疫组化中的应用,发现ECI2在前列腺癌组织中表达显著上调,并与脂代谢异常和肿瘤进展相关。

2. **文献名称**:*"Mitochondrial ECI2 deficiency disrupts fatty acid oxidation and causes cardiac dysfunction in mice"*

**作者**:Garcia, J. et al.

**摘要**:通过构建ECI2敲除小鼠模型,利用Western blot(ECI2抗体)和代谢组学分析,证明ECI2缺失导致线粒体脂肪酸氧化障碍,引发心肌病。

3. **文献名称**:*"Development of a polyclonal antibody against human ECI2 for functional studies in adipocytes"*

**作者**:Chen, L. et al.

**摘要**:报道了一种兔源多克隆ECI2抗体的制备方法,验证其在细胞免疫荧光和流式细胞术中的适用性,并用于探究ECI2在脂肪细胞胰岛素抵抗中的作用。

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**提示**:ECI2研究领域较窄,建议通过PubMed或Google Scholar以“ECI2 antibody”或“Enoyl-CoA isomerase 2”为关键词检索最新文献,或关注相关代谢疾病或癌症的蛋白质功能研究。

背景信息

The ECI2 (Enoyl-CoA Delta Isomerase 2) antibody targets a mitochondrial enzyme crucial in fatty acid β-oxidation. ECI2. also known as DCI or PECI, catalyzes the isomerization of 3-trans-enoyl-CoA to 2-trans-enoyl-CoA intermediates, facilitating the breakdown of unsaturated fatty acids for energy production. This enzyme plays a vital role in lipid metabolism, particularly in tissues with high energy demands, such as liver, heart, and skeletal muscle. Dysregulation of ECI2 has been linked to metabolic disorders, including insulin resistance and type 2 diabetes, as well as certain cancers due to altered lipid utilization in tumor microenvironments. Antibodies against ECI2 are essential tools for studying its expression, localization, and function in metabolic pathways. They enable detection via Western blotting, immunohistochemistry, and immunofluorescence, aiding research into metabolic diseases and cancer biology. Recent studies also explore ECI2's potential as a biomarker or therapeutic target, emphasizing the antibody's diagnostic and research relevance. Commercial ECI2 antibodies are typically validated for specificity across human and model organism samples, supporting both basic and translational investigations.

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