| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Purified recombinant fragment of human PPP1R9B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是模拟生成的关于PPP1R9B抗体的参考文献示例(实际文献请通过学术数据库核实)：
---
1. **"Characterization of PPP1R9B in synaptic plasticity using a novel monoclonal antibody"**
*Author: Tanaka S, et al.*
摘要：本研究开发了一种针对PPP1R9B(Neurabin-2)的高特异性单克隆抗体，并通过免疫印迹和免疫组化验证其有效性。研究揭示了PPP1R9B在海马神经元突触后膜中的定位，并证明其通过与蛋白磷酸酶1(PP1)相互作用调控突触可塑性。
2. **"PPP1R9B regulates cancer cell motility via actin cytoskeleton remodeling"**
*Author: Chen L, Wang X.*
摘要：通过免疫共沉淀和siRNA沉默技术，该研究发现PPP1R9B在乳腺癌细胞中高表达，其抗体检测显示其与肌动蛋白结合蛋白的相互作用，提示PPP1R9B通过调节细胞骨架动态影响肿瘤转移。
3. **"A role of PPP1R9B in dopamine receptor signaling revealed by antibody-mediated knockdown"**
*Author: Smith J, et al.*
摘要：利用定制兔多克隆抗体阻断PPP1R9B功能，发现其在小鼠纹状体中调控多巴胺D2受体的信号转导，表明PPP1R9B可能作为神经精神疾病的潜在治疗靶点。
---
**注**：以上文献为模拟生成，建议通过PubMed或Google Scholar搜索“PPP1R9B antibody”、“Neurabin-2 antibody”等关键词获取真实文献。
The PPP1R9B antibody targets the protein PPP1R9B (Protein Phosphatase 1 Regulatory Subunit 9B), also known as Neurabin-2. This protein is a regulatory subunit of protein phosphatase 1 (PP1), a serine/threonine phosphatase critical for cellular signaling. PPP1R9B is predominantly expressed in the brain, where it localizes to dendritic spines and interacts with cytoskeletal components, neurotransmitter receptors, and signaling molecules. It plays a role in synaptic plasticity, neuronal morphology, and receptor trafficking, particularly modulating dopamine receptor signaling and AMPA receptor (AMPAR) internalization.
Antibodies against PPP1R9B are widely used in neuroscience research to study its expression, subcellular distribution, and interactions. They are employed in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to explore its involvement in neurological and psychiatric disorders, including schizophrenia, Parkinson’s disease, and addiction. Additionally, PPP1R9B has been implicated in cancer due to its regulatory effects on cell motility and metastasis-related pathways.
Validated PPP1R9B antibodies are essential for distinguishing it from its homolog, Neurabin-1 (PPP1R9A), and assessing post-translational modifications. Researchers often verify specificity using knockout controls or siRNA knockdown. Understanding PPP1R9B's role through antibody-based studies contributes to insights into synaptic dysfunction and disease mechanisms, highlighting its potential as a therapeutic target.
×
