| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MATN2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于MATN2抗体的3篇参考文献示例，内容基于典型研究主题归纳：
1. **"Matrilin-2 (MATN2) in extracellular matrix remodeling and cancer progression"**
*作者：Smith A, et al.*
摘要：本研究通过MATN2抗体进行免疫组化分析，揭示MATN2在多种癌细胞系及肿瘤组织中的高表达，并发现其通过调控TGF-β信号通路促进肿瘤侵袭和转移。
2. **"MATN2 deficiency disrupts skeletal development by altering collagen fibrillogenesis"**
*作者：Chen L, et al.*
摘要：利用MATN2抗体在小鼠模型中进行Western blot和免疫荧光实验，证明MATN2缺失导致胶原纤维组装异常，影响骨骼发育和关节稳定性。
3. **"Proteomic profiling identifies MATN2 as a biomarker for diabetic nephropathy"**
*作者：Wang Y, et al.*
摘要：通过ELISA和免疫印迹结合MATN2抗体，发现糖尿病肾病患者尿液中MATN2水平显著升高，提示其可作为肾脏纤维化的潜在生物标志物。
注：以上文献为示例性概括，实际引用需根据具体研究检索数据库(如PubMed)获取准确信息。
The MATN2 antibody is a tool used to detect matrilin-2 (MATN2), a multifunctional extracellular matrix (ECM) protein belonging to the matrilin family. Matrilin-2 is characterized by von Willebrand factor A (vWFA) domains and epidermal growth factor (EGF)-like repeats, which mediate interactions with other ECM components like collagen and proteoglycans. It plays a role in tissue development, ECM assembly, and cell adhesion, particularly in elastic tissues such as cartilage, blood vessels, and the nervous system. MATN2 is also implicated in modulating signaling pathways involved in tissue repair, inflammation, and tumorigenesis.
Antibodies targeting MATN2 are widely used in research to study its expression, localization, and function in both normal and pathological conditions. For example, they help investigate MATN2's involvement in diseases like osteoarthritis, cardiovascular disorders, and cancers, where altered ECM remodeling is observed. These antibodies are employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to visualize MATN2 in tissue samples or cell cultures. Some studies also explore MATN2's potential as a biomarker for disease progression or therapeutic targeting. Researchers must validate MATN2 antibodies for specificity, as cross-reactivity with other matrilin family members (e.g., MATN1. MATN3) could occur due to structural similarities. Overall, MATN2 antibodies serve as critical reagents for unraveling the protein's biological roles and its translational relevance in human health.
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