Mouse Monoclonal DMXL2 Antibody

The DMXL2 antibody is a research tool designed to detect DMXL2 (Dmx-like 2), a protein encoded by the DMXL2 gene. This gene belongs to the DMX family, which shares homology with the Drosophila melanogaster Dmx gene. DMXL2 is a large, multidomain protein containing WD40 repeats, suggesting roles in protein-protein interactions and cellular signaling. It is implicated in regulating vesicular trafficking, neurotransmitter release, and secretory pathways, particularly in neuronal and endocrine tissues. Studies link DMXL2 to the Rab6-regulated pathway and the assembly of the V-ATPase complex, which is critical for lysosomal and synaptic vesicle acidification. Dysregulation of DMXL2 has been associated with neurological disorders, including epilepsy and intellectual disability, as well as cancers like neuroendocrine tumors. The DMXL2 antibody is widely used in Western blotting, immunohistochemistry, and immunofluorescence to study its expression, localization, and interactions in disease models. Recent research also explores its potential role in autophagy and apoptosis. Commercial DMXL2 antibodies are typically raised against specific epitopes, often validated in knockout controls to ensure specificity. Ongoing studies aim to clarify its mechanistic contributions to cellular homeostasis and pathology.