| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human DMXL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3-4条关于DMXL2抗体的虚构参考文献示例(仅供学术写作参考，非真实文献)：
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1. **标题**: "DMXL2 modulates secretory granule biogenesis in neuroendocrine tumors"
**作者**: Tanaka K, et al.
**摘要**: 本研究利用DMXL2特异性抗体，通过免疫组化和Western blot分析了其在胰腺神经内分泌肿瘤中的表达。发现DMXL2高表达与肿瘤细胞分泌颗粒异常相关，提示其可能通过调控囊泡运输通路影响肿瘤发生。
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2. **标题**: "Developmental expression of DMXL2 in murine brain: Insights from antibody-based localization"
**作者**: Chen L, et al.
**摘要**: 通过抗DMXL2抗体的免疫荧光染色，揭示了DMXL2在小鼠胚胎及出生后大脑皮层和海马区的动态表达模式，提示其在神经元分化和突触形成中的潜在作用。
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3. **标题**: "DMXL2 interacts with the Wnt/β-catenin pathway in colorectal cancer progression"
**作者**: Gupta R, et al.
**摘要**: 结合CRISPR敲除技术和DMXL2抗体染色，发现DMXL2通过稳定β-catenin蛋白促进结直肠癌细胞侵袭，其表达水平与患者预后呈负相关。
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4. **标题**: "Antibody validation for DMXL2: Specificity and functional implications in gastric epithelial cells"
**作者**: Müller S, et al.
**摘要**: 系统性验证了商业DMXL2抗体的特异性(通过siRNA敲除对照)，并应用于胃黏膜组织芯片分析，揭示DMXL2在幽门螺杆菌感染相关癌变中的上调表达。
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注：以上文献为模拟内容，实际研究中请通过PubMed等数据库检索真实文献。如需进一步构造特定方向的内容，可提供补充信息。
The DMXL2 (Dmx-like 2) antibody targets the DMXL2 protein, a member of the WD40 repeat-containing protein family encoded by the DMXL2 gene. DMXL2 is evolutionarily conserved and widely expressed in tissues, particularly in the brain, endocrine cells, and secretory pathways. It plays a critical role in intracellular vesicle trafficking, synaptic function, and regulation of secretory processes, including neurotransmitter and hormone release. Structurally, DMXL2 contains multiple WD40 domains, enabling interactions with diverse proteins to form complexes involved in signaling and transport.
Research highlights DMXL2's involvement in Rab GTPase-mediated vesicle docking/fusion via its association with Rabconnectin-3 complexes. Dysregulation of DMXL2 is linked to neurological disorders (e.g., epilepsy, intellectual disability) and endocrine tumors, possibly due to altered vesicle dynamics or secretory pathway malfunctions. The DMXL2 antibody is a key tool for studying these mechanisms, enabling detection of protein expression, localization, and interactions in models like neurons or cancer cells. Its applications span Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into DMXL2's role in development, disease, and cellular homeostasis. Validated specificity and cross-reactivity data are essential for reliable experimental outcomes.
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