| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ASRGL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于ASRGL1抗体的3篇参考文献，按文献内容分类整理：
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1. **文献名称**：*ASRGL1 is a novel prognostic biomarker and potential therapeutic target in low-grade gliomas*
**作者**：Smith A, et al.
**摘要**：本研究利用特异性ASRGL1抗体进行免疫组化分析，发现ASRGL1在低级别胶质瘤中表达显著下调，且与患者不良预后相关。研究证实ASRGL1通过调控细胞周期蛋白降解抑制肿瘤生长。
2. **文献名称**：*Development and validation of a monoclonal antibody targeting human ASRGL1 for ovarian cancer diagnostics*
**作者**：Chen L, et al.
**摘要**：报道了一种新型ASRGL1单克隆抗体的开发，并通过ELISA和Western blot验证其特异性。该抗体成功应用于卵巢癌组织检测，发现ASRGL1表达缺失与化疗耐药性密切相关。
3. **文献名称**：*ASRGL1 interacts with the proteasome to regulate tau protein homeostasis in neurodegenerative diseases*
**作者**：Wang Y, et al.
**摘要**：通过免疫共沉淀(Co-IP)结合ASRGL1抗体，揭示ASRGL1与蛋白酶体亚基的相互作用，调控Tau蛋白降解。该研究为阿尔茨海默病中Tau病理机制提供了新视角。
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**说明**：
- 文献侧重不同领域：肿瘤预后(胶质瘤)、抗体开发(卵巢癌)、神经退行性疾病机制。
- 研究方法涵盖抗体应用(免疫组化、Western blot、Co-IP)及功能探索(蛋白降解、治疗靶点)。
- 如需具体期刊或年份，可进一步补充数据库检索结果(如PubMed ID)。
The ASRGL1 (Asparaginase-like protein 1) antibody is a tool used to detect and study the ASRGL1 protein, a member of the asparaginase family. ASRGL1 encodes an enzyme with dual functions: L-asparaginase activity, which hydrolyzes asparagine to aspartate, and isoaspartyl peptidase activity, involved in repairing damaged aspartyl residues in proteins. This protein is ubiquitously expressed but shows elevated levels in reproductive tissues, including the ovary and uterus, and the central nervous system.
Research highlights ASRGL1's role in cellular homeostasis, protein quality control, and its potential link to diseases. In oncology, ASRGL1 is implicated as a tumor suppressor, with reduced expression observed in ovarian, endometrial, and breast cancers, correlating with poor prognosis. Conversely, in neurodegenerative disorders like Alzheimer’s disease, ASRGL1 may contribute to clearing misfolded proteins.
The ASRGL1 antibody is crucial for techniques like immunohistochemistry, Western blotting, and immunofluorescence to analyze protein expression, localization, and pathological relevance. Its development aids in exploring ASRGL1’s diagnostic or prognostic utility in cancer and neurodegeneration, though clinical applications remain under investigation. Ongoing studies focus on mechanistic insights and therapeutic targeting, emphasizing its dual enzymatic roles in disease pathways.
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