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Mouse Monoclonal ID4 Antibody

  • 中文名: ID4抗体
  • 别    名: nan
货号: IPDX16168
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ID4
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于ID4抗体的3篇参考文献的示例(注:文献信息为模拟示例,实际引用请查询真实数据库):

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1. **文献名称**: *ID4 suppresses tumor growth and chemoresistance in triple-negative breast cancer via inhibition of TCF1-LEF1*

**作者**: Zhang Y, et al.

**摘要**: 研究利用ID4抗体进行免疫印迹和免疫组化,发现ID4通过抑制Wnt/β-catenin通路降低三阴性乳腺癌的化疗耐药性,提示其作为治疗靶点的潜力。

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2. **文献名称**: *Epigenetic silencing of ID4 promotes glioblastoma progression by regulating stem cell markers*

**作者**: Patel SA, et al.

**摘要**: 通过ID4抗体检测发现,ID4在胶质母细胞瘤中因甲基化沉默,其表达缺失与肿瘤干细胞特性增强相关,靶向ID4可抑制肿瘤侵袭。

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3. **文献名称**: *ID4 regulates neuronal differentiation during cortical development*

**作者**: Lee HJ, et al.

**摘要**: 研究利用ID4抗体进行免疫荧光染色,揭示ID4在小鼠皮层发育中调控神经前体细胞分化的机制,缺失ID4导致神经元迁移异常。

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**提示**:实际研究中建议通过PubMed或Web of Science检索关键词“ID4 antibody”、“ID4 cancer”等,筛选涉及抗体应用的实验论文。部分真实文献可能包括:

- *Oncogene* 2021年关于ID4在结肠癌中的研究

- *Nature Cell Biology* 2019年探讨ID4与干细胞干性的文章

背景信息

The ID4 (Inhibitor of DNA Binding 4) antibody targets the ID4 protein, a member of the ID protein family (ID1-4) that regulates cell differentiation and proliferation by interacting with basic helix-loop-helix (bHLH) transcription factors. Unlike other ID proteins, ID4 contains unique structural features, including an extended N-terminal region, and is primarily expressed during embryonic development and in specific adult tissues like the brain, testes, and kidneys. It functions as a dominant-negative regulator by binding to bHLH transcription factors, preventing their DNA interaction, thereby influencing cell cycle progression, stem cell maintenance, and differentiation. Dysregulation of ID4 is implicated in cancers, where it may act as a tumor suppressor or oncogene depending on context. For example, ID4 silencing via promoter hypermethylation is observed in colorectal and gastric cancers, while its overexpression correlates with poor prognosis in breast and ovarian cancers. ID4 antibodies are essential tools for detecting ID4 expression in research and diagnostics, helping to elucidate its role in disease mechanisms. Recent studies also explore ID4's potential as a therapeutic target, particularly in cancers with aberrant ID4 activity. These antibodies enable the study of ID4's interactions with signaling pathways (e.g., TGF-β, Notch) and its impact on epithelial-mesenchymal transition (EMT) and apoptosis.

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