| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IMMT |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于IMMT抗体的参考文献示例(注：以下内容为假设性示例，实际文献需通过学术数据库查询)：
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1. **文献名称**：*The role of IMMT/MIC60 in mitochondrial cristae morphology and apoptosis*
**作者**：Smith A, et al.
**摘要**：本研究利用IMMT特异性抗体，通过免疫荧光和电镜技术，揭示了IMMT蛋白在线粒体嵴结构形成中的关键作用。实验表明，IMMT缺失会导致嵴结构紊乱并增强细胞凋亡敏感性。
2. **文献名称**：*IMMT antibody-based profiling of mitochondrial dysfunction in neurodegenerative diseases*
**作者**：Zhang L, et al.
**摘要**：通过IMMT抗体对阿尔茨海默病患者脑组织样本进行Western blot分析，发现IMMT表达水平显著降低，提示其可能与线粒体功能障碍及神经元退行性病变相关。
3. **文献名称**：*IMMT as a biomarker in cancer: Insights from immunohistochemical analysis*
**作者**：Brown K, et al.
**摘要**：本研究利用IMMT抗体对多种癌症组织进行免疫组化检测，发现IMMT表达与肿瘤代谢重编程相关，低表达患者预后较差，表明其作为潜在癌症生物标志物的价值。
4. **文献名称**：*Development and validation of a high-affinity monoclonal antibody for IMMT detection*
**作者**：Yamamoto T, et al.
**摘要**：报道了一种新型IMMT单克隆抗体的开发与验证，该抗体在ELISA和免疫沉淀实验中表现出高特异性，为研究线粒体内膜蛋白复合物提供了可靠工具。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“IMMT antibody”、“MIC60”或“mitochondrial inner membrane translocase”。
The IMMT antibody targets the inner mitochondrial membrane (IMM) protein, also known as MIC60 or mitofilin, encoded by the *IMMT* gene. This protein is a core component of the mitochondrial contact site and cristae organizing system (MICOS), critical for maintaining cristae structure—the folds in the IMM essential for ATP production. IMMT/MIC60 facilitates cristae junction formation, stabilizes membrane architecture, and mediates interactions between the IMM and outer mitochondrial membrane (OMM). It plays a role in mitochondrial dynamics, energy metabolism, and apoptosis regulation.
Antibodies against IMMT are widely used in research to study mitochondrial morphology, function, and dysfunction. They help detect IMMT expression via techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding investigations into mitochondrial disorders, neurodegenerative diseases (e.g., Parkinson’s), and cancer. Altered IMMT levels correlate with disrupted cristae structure, impaired oxidative phosphorylation, and apoptosis resistance in tumors. IMMT antibodies also contribute to exploring MICOS complex interactions and mitochondrial responses to stressors like oxidative damage. Their application advances understanding of mitochondrial biology and disease mechanisms linked to IMMT dysregulation.
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