| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human S100A12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于S100A12抗体的3篇示例文献(内容为虚构示例，仅供参考)：
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1. **文献名称**：*S100A12 as a Biomarker in Inflammatory Bowel Disease: Development of a Novel Monoclonal Antibody*
**作者**：Smith J, et al.
**摘要**：研究团队开发了一种高特异性抗S100A12单克隆抗体，通过ELISA和免疫组化验证其在炎症性肠病患者血清和组织中的检测效果，证明S100A12水平与疾病活动度显著相关。
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2. **文献名称**：*Role of S100A12 Antibody in Diagnosing Atherosclerotic Plaque Inflammation*
**作者**：Wang L, et al.
**摘要**：利用抗S100A12抗体进行动脉粥样硬化斑块的免疫荧光分析，发现S100A12在斑块炎症区域高表达，提示其可作为心血管疾病炎症活动的潜在诊断标志物。
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3. **文献名称**：*Comparative Study of Commercial S100A12 Antibodies for Rheumatoid Arthritis Detection*
**作者**：Kim H, et al.
**摘要**：对比分析四种市售抗S100A12抗体的灵敏度和特异性，发现抗体Clone 3B8在类风湿关节炎滑膜液检测中表现最优，为临床选择可靠试剂提供依据。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词(如"S100A12 antibody" + "biomarker" / "diagnosis")。
S100A12. also known as calgranulin C, is a calcium-binding protein belonging to the S100 family, predominantly expressed in granulocytes, monocytes, and some epithelial cells. It plays a role in inflammation, immune response, and cell differentiation by interacting with receptors like RAGE (Receptor for Advanced Glycation End Products), modulating intracellular signaling pathways. Elevated S100A12 levels are linked to inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, and chronic kidney disease, making it a biomarker for inflammatory processes.
S100A12 antibodies are essential tools in research and diagnostics. Polyclonal or monoclonal antibodies targeting S100A12 enable its detection in tissues (via immunohistochemistry) and biological fluids (using ELISA or Western blot). These antibodies help elucidate its role in disease mechanisms, such as neutrophil activation or endothelial dysfunction. Clinically, S100A12 antibodies aid in monitoring disease activity or response to therapy in autoimmune and chronic inflammatory conditions. Recent studies also explore their therapeutic potential, such as blocking S100A12-RAGE interactions to mitigate inflammation. Despite progress, challenges remain in standardizing assays and understanding context-specific roles across diseases. Ongoing research focuses on refining antibody specificity and exploring translational applications in personalized medicine.
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