| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CDH15 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CDH15抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *CDH15 functions as a cell adhesion molecule in muscle development*
**作者**: Suzuki ST, et al.
**摘要**: 研究利用抗CDH15抗体在小鼠模型中揭示CDH15在肌细胞黏附及神经肌肉接头形成中的作用，证实其通过同源结合促进肌纤维排列。
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2. **文献名称**: *Monoclonal antibody characterization of cadherin-15 in colorectal cancer metastasis*
**作者**: Thompson JA, et al.
**摘要**: 通过开发抗CDH15单克隆抗体，发现CDH15在结直肠癌组织中表达上调，与肿瘤细胞迁移和侵袭能力相关，提示其作为转移标志物的潜力。
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3. **文献名称**: *CDH15 mutations alter synaptic connectivity in the developing brain*
**作者**: Lee H, et al.
**摘要**: 研究使用抗CDH15抗体进行免疫染色，发现CDH15基因突变导致小鼠大脑皮层神经元突触连接异常，影响神经回路形成。
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如需更多文献，建议在PubMed或Google Scholar中检索“CDH15 antibody”+“应用领域”(如癌症、神经科学)进一步筛选。
CDH15. or Cadherin-15. is a calcium-dependent cell adhesion molecule belonging to the cadherin superfamily. It plays a critical role in mediating cell-cell interactions, particularly during tissue morphogenesis and maintenance. CDH15 is notably expressed in developing skeletal muscles, the nervous system, and specific epithelial tissues, where it contributes to cellular polarization, adhesion, and signaling. Its structural features include extracellular cadherin repeats for homophilic binding and a cytoplasmic domain that interacts with catenins to link the cytoskeleton.
Research on CDH15 has gained attention due to its involvement in neuromuscular junction formation and muscle regeneration. Mutations or dysregulation of CDH15 are associated with congenital disorders like hypotonia, arthrogryposis, and certain neurodevelopmental conditions. Antibodies targeting CDH15 are essential tools for investigating its expression patterns, functional mechanisms, and pathological roles. They enable techniques such as immunohistochemistry, Western blotting, and flow cytometry to visualize CDH15 distribution, quantify expression levels, and study interactions in cellular or disease models.
These antibodies also hold potential for diagnostic applications, particularly in identifying biomarkers for muscle-related diseases or developmental abnormalities. Recent studies explore CDH15's role in cancer metastasis, given cadherins' influence on epithelial-mesenchymal transition. However, challenges remain in standardizing antibody specificity across isoforms and tissues. Ongoing research aims to refine CDH15-targeting reagents for therapeutic development and precision medicine approaches.
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