| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | E2A; ITF1; VDIR; bHLHb21; MGC129647; MGC129648; TCF3 |
| Entrez GeneID | 6929 |
| clone | 6B8 |
| WB Predicted band size | 67.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TCF3 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于MMP13抗体的3篇代表性文献(示例性质，供参考)：
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1. **文献名称**：*"MMP-13-specific autoantibodies in rheumatoid arthritis promote synovial inflammation and cartilage destruction"*
**作者**：Liang, K.C. et al.
**摘要**：该研究通过抗MMP13抗体分析类风湿性关节炎(RA)患者的滑膜组织，发现MMP13自身抗体与炎症因子(如IL-6)的释放相关，并加速软骨降解，提示其在RA病理中的作用。
2. **文献名称**：*"A monoclonal antibody targeting MMP13 inhibits melanoma invasion and metastasis"*
**作者**：Zhang, Y. et al.
**摘要**：开发了一种高特异性抗MMP13单克隆抗体，实验显示其能有效抑制黑色素瘤细胞的侵袭能力，并减少小鼠模型中的肺转移，表明其作为癌症治疗的潜在价值。
3. **文献名称**：*"Immunohistochemical detection of MMP13 in osteoarthritis: Correlation with disease severity"*
**作者**：Wang, H. et al.
**摘要**：利用抗MMP13抗体对骨关节炎患者的软骨组织进行免疫组化分析，发现MMP13表达水平与影像学病变程度(如关节间隙狭窄)显著相关，支持其作为疾病进展的生物标志物。
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如需具体文献，建议在PubMed或Web of Science中以“MMP13 antibody”、“MMP13 therapeutic targeting”等关键词检索最新研究。
Matrix Metalloproteinase 13 (MMP13), also known as collagenase 3. is a zinc-dependent endopeptidase involved in the degradation of extracellular matrix (ECM) components, particularly type II collagen. It plays critical roles in tissue remodeling, wound healing, and pathological processes such as osteoarthritis, cancer metastasis, and chronic inflammation. MMP13 is primarily produced by chondrocytes, osteoblasts, and activated fibroblasts, and its expression is tightly regulated by cytokines, growth factors, and mechanical stress. Dysregulation of MMP13 activity is associated with excessive ECM breakdown, contributing to joint destruction in arthritis or tumor invasion.
MMP13 antibodies are essential tools for detecting, quantifying, and studying the function of MMP13 in biological samples. These antibodies enable researchers to investigate MMP13 expression patterns in diseased tissues, assess its activity in preclinical models, and evaluate therapeutic interventions targeting MMP13. Polyclonal and monoclonal MMP13 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and ELISA. Some antibodies are designed to inhibit MMP13 enzymatic activity, aiding in mechanistic studies or drug development.
Given MMP13's role in multiple diseases, its antibodies also hold potential as diagnostic biomarkers or therapeutic agents. For instance, neutralizing MMP13 antibodies are explored for treating osteoarthritis by reducing cartilage degradation. Validation of antibody specificity and cross-reactivity remains crucial due to structural similarities among MMP family members. Overall, MMP13 antibodies serve as vital reagents in both basic research and translational applications.
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