首页 / 产品 / 抗体 / 一抗

Mouse Monoclonal VASH1 Antibody

  • 中文名: VASH1抗体
  • 别    名: nan
货号: IPDX15848
Price: ¥1280
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

参考文献

以下是关于VASH1抗体的3篇假设性参考文献示例(基于公开研究主题,非真实文献):

---

1. **文献名称**: *"Vasohibin-1 (VASH1) as a novel biomarker for tumor angiogenesis and prognosis in colorectal cancer"*

**作者**: Shibuya T, et al.

**摘要**: 本研究通过免疫组化和Western blot技术,使用VASH1特异性抗体检测结直肠癌组织中VASH1的表达水平,发现其高表达与肿瘤血管密度降低及患者生存期延长显著相关,提示VASH1可能通过抑制血管生成影响肿瘤进展。

2. **文献名称**: *"VASH1 modulates the immunosuppressive tumor microenvironment by regulating TAM polarization"*

**作者**: Hosoda Y, et al.

**摘要**: 研究利用VASH1抗体进行免疫荧光共定位分析,揭示VASH1在肿瘤相关巨噬细胞(TAMs)中的表达可抑制M2型极化,并通过阻断VEGF信号通路减少免疫抑制性微环境形成,为靶向VASH1的免疫治疗提供依据。

3. **文献名称**: *"Dynamic expression of VASH1 in vascular injury and its role in arterial remodeling"*

**作者**: Kimura H, et al.

**摘要**: 通过免疫染色和流式细胞术结合VASH1抗体,发现VASH1在血管损伤后早期上调,并通过抑制平滑肌细胞过度增殖减轻动脉再狭窄,提示其可能成为治疗血管增生性疾病的靶点。

---

**注**: 以上文献为示例,实际研究中建议通过PubMed或Google Scholar以“VASH1 antibody”或“Vasohibin-1”为关键词检索最新论文。

背景信息

The vasohibin-1 (VASH1) antibody is a tool used to detect and study the VASH1 protein, a member of the vasohibin family involved in regulating angiogenesis. VASH1 is primarily expressed in endothelial cells and functions as a negative feedback regulator of blood vessel formation, counteracting pro-angiogenic signals. It modulates microtubule dynamics by promoting detyrosination, a post-translational modification linked to cellular stability and migration. Research highlights its dual role: while it suppresses pathological angiogenesis in conditions like cancer and retinopathy, it may also promote vascular normalization in tumors. VASH1 antibodies are utilized in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to analyze its expression, localization, and interaction with other proteins. Studies associate VASH1 with tumor progression, metastasis, and clinical outcomes, suggesting its potential as a therapeutic target or biomarker. However, its context-dependent functions necessitate careful interpretation of experimental results. Commercial VASH1 antibodies vary in specificity, so validation using knockout controls is critical for reliable data.

客户数据及评论

折叠内容

大包装询价

×