| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human STX17 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于STX17抗体的参考文献示例(注：以下为模拟示例，具体文献需根据实际研究检索)：
1. **"Syntaxin 17 regulates autophagosome maturation by mediating fusion with lysosomes"**
- **作者**: Tamura N, et al.
- **摘要**: 本研究通过免疫沉淀和免疫荧光技术，利用STX17抗体证实了Syntaxin 17在自噬体与溶酶体膜融合中的关键作用，揭示了其在自噬通量调控中的分子机制。
2. **"STX17-dependent vesicle trafficking promotes hepatocellular carcinoma metastasis"**
- **作者**: Zhao Y, et al.
- **摘要**: 通过免疫组织化学(使用STX17抗体)和基因敲除实验，发现STX17通过调控囊泡运输促进肝癌细胞侵袭转移，其高表达与患者不良预后相关。
3. **"STX17 interacts with Parkinson's disease-associated proteins and modulates mitochondrial clearance"**
- **作者**: Smith J, et al.
- **摘要**: 研究利用STX17抗体进行Western blot和共聚焦成像，证明STX17与PINK1/Parkin通路协同调控线粒体自噬，为帕金森病病理机制提供了新见解。
4. **"A novel role for STX17 in maintaining endoplasmic reticulum homeostasis"**
- **作者**: Chen L, et al.
- **摘要**: 通过STX17抗体的功能阻断实验，发现STX17参与内质网应激响应，调控未折叠蛋白的降解途径，影响细胞存活。
(建议通过PubMed或Web of Science以“STX17 antibody”为关键词检索最新文献获取具体研究。)
The STX17 (syntaxin 17) antibody is a key tool for studying the molecular mechanisms of membrane trafficking and autophagy. STX17. a member of the SNARE protein family, plays a critical role in mediating membrane fusion events, particularly in autophagosome-lysosome fusion during autophagy. Discovered as a transmembrane protein localized to the endoplasmic reticulum (ER) and autophagosomes, STX17 interacts with partners like SNAP-29 and VAMP8 to facilitate autophagosome maturation. Its involvement in autophagy regulation has linked it to diseases such as cancer, neurodegeneration, and metabolic disorders.
Research using STX17 antibodies has revealed its dynamic recruitment to autophagosomal membranes during nutrient deprivation, where it coordinates lysosomal degradation of cellular components. These antibodies are widely employed in techniques like Western blotting, immunofluorescence, and immunoprecipitation to assess STX17 expression, subcellular localization, and protein interactions. Studies have also highlighted STX17’s role beyond autophagy, including secretory pathways and mitochondrial dynamics.
The antibody’s specificity often targets epitopes in STX17’s N-terminal or C-terminal domains, aiding in functional studies. Its development has been pivotal in validating knockout models and exploring therapeutic targets for autophagy-related disorders. Overall, STX17 antibodies remain essential for dissecting membrane trafficking mechanisms and their implications in health and disease.
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