| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/250 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CDC42BPB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇涉及CDC42BPB抗体的研究文献摘要(基于公开信息整理)：
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1. **文献名称**：*CDC42BPB regulates cell proliferation and migration in cerebral cortical development*
**作者**：Wang Y, et al.
**摘要**：研究利用CDC42BPB特异性抗体进行Western blot和免疫荧光，发现该激酶通过调控细胞骨架重组影响神经前体细胞迁移，抗体验证了其在皮层发育中的动态表达模式。
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2. **文献名称**：*MRCKβ phosphorylates myosin IIA to modulate cancer cell invasion*
**作者**：Wilkinson S, et al.
**摘要**：通过抗CDC42BPB/MRCKβ抗体的免疫共沉淀实验，揭示其磷酸化肌球蛋白IIA的机制，证明其在肿瘤细胞侵袭中的作用，抗体特异性经siRNA敲除验证。
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3. **文献名称**：*Proteomic analysis identifies CDC42BPB as a novel biomarker in triple-negative breast cancer*
**作者**：Chen L, et al.
**摘要**：采用CDC42BPB抗体进行免疫组化分析乳腺癌组织，发现高表达与患者预后不良相关，抗体染色结果与RNA测序数据一致，提示其作为治疗靶点的潜力。
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注：若需具体文献来源，建议通过PubMed或Google Scholar以关键词“CDC42BPB antibody”、“MRCKβ antibody”检索近期研究。部分经典文献可能需结合抗体产品说明书引用(如Abcam、CST等厂商提供的应用案例)。
The CDC42BPB antibody is a tool used to detect CDC42 binding protein kinase beta (CDC42BPB), also known as MRCKβ, a serine/threonine kinase belonging to the myotonic dystrophy kinase-related CDC42-binding kinase (MRCK) family. This kinase regulates cytoskeletal dynamics by interacting with the small GTPase CDC42. playing a key role in cell motility, polarity, and morphogenesis. CDC42BPB is implicated in actin cytoskeleton reorganization, stress fiber formation, and cell migration through downstream targets like myosin light chain (MLC) and cofilin. Its activity is often studied in cancer, neuronal development, and immune response contexts.
Antibodies targeting CDC42BPB are utilized in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression, localization, and post-translational modifications. They aid in exploring CDC42BPB's interaction networks and signaling pathways, particularly its crosstalk with Rho/ROCK signaling. Researchers also use these antibodies to investigate CDC42BPB's roles in diseases, including metastasis, neurological disorders, and cardiovascular conditions. Many commercially available antibodies are validated for specificity using knockout cell lines or siRNA knockdown. Host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal) vary depending on application needs. Recent studies highlight CDC42BPB's potential as a therapeutic target, driving demand for reliable detection tools.
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