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Mouse Monoclonal ITGB1BP1 Antibody

  • 中文名: ITGB1BP1抗体
  • 别    名: nan
货号: IPDX15812
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ITGB1BP1
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于ITGB1BP1抗体的3篇参考文献及其摘要内容:

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1. **文献名称**: "ICAP-1 (ITGB1BP1) Modulates β1-Integrin Activation and Cell Adhesion"

**作者**: Bouvard, D. et al.

**摘要**: 该研究利用特异性抗ITGB1BP1抗体,证明ICAP-1通过调控β1整合素的构象变化影响细胞黏附,揭示其在细胞迁移中的抑制作用。抗体被用于免疫沉淀和Western blot验证蛋白互作。

2. **文献名称**: "MIBP1 (ITGB1BP1) Antibody as a Biomarker for Tumor Metastasis in Lung Cancer"

**作者**: Chen, L. et al.

**摘要**: 研究开发了一种高特异性抗ITGB1BP1单克隆抗体,通过免疫组化检测肺癌组织中MIBP1的表达水平,发现其低表达与肿瘤转移和患者预后不良显著相关。

3. **文献名称**: "Functional Characterization of ITGB1BP1 in Angiogenesis Using Knockout Models and Antibody Blocking"

**作者**: Tanaka, H. et al.

**摘要**: 通过抗ITGB1BP1抗体的阻断实验,结合基因敲除模型,证明ITGB1BP1通过调控内皮细胞整合素信号通路参与血管生成,抗体在此过程中用于抑制蛋白功能验证。

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注:上述文献为示例,实际引用时需根据具体论文内容调整。建议通过PubMed或Google Scholar以关键词“ITGB1BP1 antibody”或“ICAP1/MIBP1 antibody”检索最新研究。

背景信息

The ITGB1BP1 antibody is designed to detect Integrin Beta-1 Binding Protein 1 (ITGB1BP1), also known as ICAP-1. a 200-amino acid cytoplasmic protein that interacts with the β1-integrin cytoplasmic domain. ITGB1BP1 regulates integrin-mediated cell adhesion, migration, and signaling by modulating β1-integrin activation, clustering, and endocytosis. It acts as a molecular switch, competing with talin for β1-integrin binding to control affinity states and downstream signaling pathways, such as FAK and MAPK. Dysregulation of ITGB1BP1 is implicated in cancer progression, angiogenesis, and fibrotic diseases due to its role in cell-extracellular matrix interactions. Researchers use ITGB1BP1 antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study its expression, localization, and function in tissue development, tumor metastasis, and wound healing. These antibodies are often validated in knockout models to ensure specificity. ITGB1BP1's involvement in critical cellular processes makes it a focus in studies exploring therapeutic targets for cancer and fibrosis. Commercial antibodies are typically raised in rabbits or mice, with reactivity confirmed across human, mouse, and rat samples. Proper controls are essential due to potential cross-reactivity with other integrin-associated proteins.

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