Mouse Monoclonal ITGB1BP1 Antibody

The ITGB1BP1 antibody is designed to detect Integrin Beta-1 Binding Protein 1 (ITGB1BP1), also known as ICAP-1. a 200-amino acid cytoplasmic protein that interacts with the β1-integrin cytoplasmic domain. ITGB1BP1 regulates integrin-mediated cell adhesion, migration, and signaling by modulating β1-integrin activation, clustering, and endocytosis. It acts as a molecular switch, competing with talin for β1-integrin binding to control affinity states and downstream signaling pathways, such as FAK and MAPK. Dysregulation of ITGB1BP1 is implicated in cancer progression, angiogenesis, and fibrotic diseases due to its role in cell-extracellular matrix interactions. Researchers use ITGB1BP1 antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study its expression, localization, and function in tissue development, tumor metastasis, and wound healing. These antibodies are often validated in knockout models to ensure specificity. ITGB1BP1's involvement in critical cellular processes makes it a focus in studies exploring therapeutic targets for cancer and fibrosis. Commercial antibodies are typically raised in rabbits or mice, with reactivity confirmed across human, mouse, and rat samples. Proper controls are essential due to potential cross-reactivity with other integrin-associated proteins.