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Mouse Monoclonal AREL1 Antibody

  • 中文名: AREL1抗体
  • 别    名: nan
货号: IPDX15809
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human AREL1
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于AREL1抗体的模拟参考文献示例(注:实际文献可能需要通过学术数据库进一步检索):

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1. **标题**:*Development and Validation of a Novel AREL1 Antibody for Studying Apoptosis Signaling*

**作者**:Zhang Y, et al.

**摘要**:该研究报道了一种高特异性AREL1单克隆抗体的开发,通过免疫印迹和免疫荧光验证其在HeLa细胞中的定位,证实AREL1在凋亡过程中与Bcl-2家族蛋白的相互作用,提示其在细胞死亡途径中的调控作用。

2. **标题**:*AREL1 Expression Profiling in Neurodegenerative Disorders Using a Custom Polyclonal Antibody*

**作者**:Martinez L, et al.

**摘要**:研究团队开发了兔源AREL1多克隆抗体,用于分析阿尔茨海默病小鼠模型脑组织中的表达变化,发现AREL1在神经元突触中的异常聚集可能与tau蛋白病理相关。

3. **标题**:*AREL1 Antibody-Based Screening Identifies Its Role in Mitochondrial Fission*

**作者**:Kim S, et al.

**摘要**:通过AREL1抗体的免疫沉淀结合质谱分析,揭示了AREL1与线粒体分裂蛋白Drp1的结合,阐明其通过调控线粒体形态影响细胞能量代谢的机制。

4. **标题**:*Arel1 Knockout Mice and Antibody Localization Reveal Cardiac Developmental Defects*

**作者**:Wang Q, et al.

**摘要**:利用AREL1抗体进行胚胎组织染色,发现Arel1基因缺失导致小鼠心脏发育异常,提示其在心肌细胞分化中的关键作用。

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**建议**:如需真实文献,可检索PubMed或Google Scholar,使用关键词“AREL1 antibody”、“FBXO42 antibody”(因AREL1可能为FBXO42别名)或结合研究领域(如凋亡、泛素化)。

背景信息

The AREL1 antibody detects the AREL1 protein (ARGLU1), a multifunctional regulator containing ankyrin repeats and a LEM domain, which facilitate interactions with proteins and RNA. Primarily involved in RNA splicing and transcriptional modulation, AREL1 influences gene expression by coordinating spliceosome activity and chromatin remodeling. It plays pivotal roles in cellular processes like proliferation, differentiation, and apoptosis. Dysregulation of AREL1 is linked to cancers (e.g., gliomas, breast cancer) and neurodevelopmental disorders, suggesting its dual impact in oncogenesis and neural function. Researchers employ AREL1 antibodies in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study its expression, localization, and interactions in disease models. These tools help unravel AREL1’s mechanistic contributions to pathological pathways, highlighting its potential as a biomarker or therapeutic target. The antibody’s specificity enables insights into AREL1’s dynamic roles across diverse biological contexts.

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