| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Purified recombinant fragment of human CA3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CA3(Carbonic Anhydrase III)抗体的3篇示例参考文献(内容为虚构示例，建议通过学术数据库查询真实文献)：
1. **文献名称**: *Carbonic Anhydrase III as a Biomarker in Skeletal Muscle Pathology*
**作者**: Smith A, Jones B
**摘要**: 本研究探讨了CA3抗体在肌肉活检中的特异性应用，发现其在骨骼肌损伤和肌病(如多发性肌炎)中可作为诊断标志物，并通过免疫组化验证了其组织特异性。
2. **文献名称**: *Autoantibodies Against CA3 in Liver Cirrhosis and Hepatocellular Carcinoma*
**作者**: Chen L, Wang H
**摘要**: 文章分析了CA3抗体在肝病患者血清中的表达，发现其水平在肝细胞癌患者中显著升高，提示CA3可能作为肝癌早期筛查的潜在血清标志物。
3. **文献名称**: *Role of CA3 in Oxidative Stress and Mitochondrial Function*
**作者**: Müller S, et al.
**摘要**: 通过CA3抗体阻断实验，揭示了CA3在调节细胞氧化应激反应中的作用，并证明其缺失会导致线粒体功能异常，与神经退行性疾病相关。
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**建议**：
- 使用PubMed、Google Scholar等平台，以关键词"CA3 antibody"或"carbonic anhydrase III antibody"检索近期文献。
- 关注抗体应用领域(如癌症、肌肉疾病、自身免疫病)以筛选目标研究。
- 使用EndNote或Zotero管理文献格式。
Carbonic anhydrase III (CA3), a member of the carbonic anhydrase enzyme family, is primarily expressed in skeletal muscle, liver, and adipose tissue. It catalyzes the reversible hydration of carbon dioxide, playing roles in pH regulation, ion transport, and metabolism. Unlike other CA isoforms, CA3 shows limited enzymatic activity but exhibits antioxidant properties, possibly protecting cells from oxidative stress.
CA3 antibodies are immunodetection tools targeting this protein, widely used in research and diagnostics. In research, they help study CA3's tissue-specific expression, its involvement in muscle disorders (e.g., Duchenne muscular dystrophy), and metabolic diseases. Elevated CA3 levels in serum or tissues have been linked to liver fibrosis, hepatocellular carcinoma, and certain renal cancers, making it a potential biomarker. Commercially available CA3 antibodies (e.g., from Sigma-Aldrich, Abcam) are validated for techniques like Western blotting, immunohistochemistry, and ELISA.
Clinically, CA3 antibodies aid in diagnosing muscle damage or monitoring disease progression. Recent studies also explore CA3's role in obesity and insulin resistance, broadening its therapeutic relevance. However, cross-reactivity with other CA isoforms requires careful antibody validation. Overall, CA3 antibodies remain critical for elucidating CA3's physiological and pathological mechanisms.
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