| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human FKBP5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于FKBP5抗体的3篇参考文献示例(内容基于已有研究主题，具体文献信息建议通过学术数据库核实)：
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1. **标题**：*Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment*
**作者**：Binder EB et al.
**摘要**：该研究探讨FKBP5基因多态性与抑郁症复发的关联，通过Western blot和免疫组化使用FKBP5抗体，发现特定基因型患者海马区FKBP5蛋白表达升高，提示其参与糖皮质激素受体信号通路异常。
2. **标题**：*Expression of FKBP5 in the prefrontal cortex of patients with schizophrenia*
**作者**：Tatro ET et al.
**摘要**：利用FKBP5特异性抗体对精神分裂症患者前额叶皮层进行免疫组化分析，发现FKBP5蛋白表达水平与神经炎症标志物呈正相关，提示其可能通过应激通路影响疾病病理。
3. **标题**：*Validation of FKBP5 antibodies for chromatin immunoprecipitation (ChIP) in stress-related models*
**作者**：Scammell JG et al.
**摘要**：本研究验证了多种FKBP5抗体的特异性，证实其在ChIP实验中的适用性，揭示FKBP5与DNA损伤修复基因启动子区域的结合，为表观遗传调控研究提供工具支持。
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**备注**：以上文献为示例性质，建议通过PubMed或Google Scholar以“FKBP5 antibody” + 应用技术(如Western blot、IHC)检索最新研究，并关注抗体验证相关论文(如《Journal of Biological Chemistry》或《Scientific Reports》中的方法学文章)。
The FKBP5 antibody is a crucial tool for studying the FK506-binding protein 5 (FKBP5), a member of the immunophilin protein family involved in regulating stress responses and glucocorticoid receptor (GR) signaling. FKBP5 acts as a co-chaperone for heat shock protein 90 (Hsp90), modulating GR sensitivity by forming a negative feedback loop. Elevated FKBP5 expression reduces GR ligand affinity, impairing stress hormone regulation and contributing to hypothalamic-pituitary-adrenal (HPA) axis dysregulation linked to psychiatric disorders like depression, PTSD, and anxiety.
FKBP5 antibodies are widely used in Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interactions in tissues or cell lines. These antibodies help explore FKBP5’s role in cellular stress adaptation, apoptosis, and immune responses. Researchers also utilize them to investigate genetic variants (e.g., rs1360780) associated with altered FKBP5 expression and disease susceptibility. Commercial FKBP5 antibodies are typically raised in rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions), with validation via knockout controls or siRNA knockdown. Their applications span neuroscience, endocrinology, and pharmacology, aiding drug development targeting FKBP5-GR interactions for stress-related disorders.
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