| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human GSTT2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于GSTT2B抗体的3篇参考文献示例(注：文献为模拟示例，实际引用需核实)：
1. **文献名称**：*Characterization of GSTT2B Antibody Specificity in Human Tissue Samples*
**作者**：Smith, J. et al.
**摘要**：本研究制备了针对GSTT2B的多克隆抗体，通过Western blot和免疫组化验证其在肝、肾组织中的特异性表达，发现GSTT2B在解毒代谢通路中显著上调。
2. **文献名称**：*Role of GSTT2B in Oxidative Stress Response: Insights from Antibody-Based Detection*
**作者**：Chen, L. & Wang, Y.
**摘要**：利用GSTT2B单克隆抗体分析其在细胞氧化应激模型中的表达变化，证实GSTT2B通过调控谷胱甘肽代谢减轻活性氧(ROS)损伤，提示其潜在治疗价值。
3. **文献名称**：*Development of a Novel ELISA Assay for GSTT2B Quantification Using Polyclonal Antibodies*
**作者**：Rodríguez, M. et al.
**摘要**：报道了一种基于兔源GSTT2B抗体的高灵敏度ELISA检测方法，成功应用于临床样本中GSTT2B蛋白水平的定量分析，并与肿瘤耐药性相关。
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**备注**：
- GSTT2B相关研究较少，上述文献为模拟，实际研究中建议通过PubMed或SciHub检索最新论文。
- 若需具体抗体品牌，可查阅供应商(如Abcam、Sigma-Aldrich)提供的引用文献。
The glutathione S-transferase theta 2B (GSTT2B) antibody is a tool used to study the GSTT2B protein, a member of the glutathione S-transferase (GST) family involved in detoxification and cellular protection. GST enzymes catalyze the conjugation of glutathione to xenobiotics, facilitating their elimination. The theta class (GSTT), including GSTT2B, is primarily associated with metabolism of halogenated compounds and reactive oxygen species. GSTT2B, located on chromosome 22q11.23. shares high sequence homology with GSTT2. its paralog, but differs in substrate specificity and tissue expression. While GSTT2 is broadly expressed, GSTT2B is considered a pseudogene in some populations due to a frameshift mutation, though low-level expression has been reported in specific tissues like the liver and testes.
Antibodies targeting GSTT2B are used to investigate its role in detoxification pathways, oxidative stress responses, and potential links to diseases such as cancer or drug resistance. However, research challenges arise due to GSTT2B's pseudogene status in certain genetic backgrounds and its high similarity to GSTT2. which may lead to cross-reactivity in assays. Validating antibody specificity through controls, such as recombinant protein or knockout models, is critical. Studies using GSTT2B antibodies contribute to understanding genetic variability in detoxification capacity and its implications for personalized medicine or environmental toxicology.
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