| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/500-1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TGM2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于TGM2抗体的3篇代表性文献摘要：
1. **文献名称**：*"Autoantibodies to tissue transglutaminase as predictors of celiac disease"*
**作者**：Dieterich W, et al. (1997)
**摘要**：该研究首次证实乳糜泻患者血清中存在的TGM2自身抗体可作为疾病特异性生物标志物，揭示了TGM2在乳糜泻发病机制中的关键作用，为临床诊断提供了重要依据。
2. **文献名称**：*"Transglutaminase 2 in the balance of cell death and survival"*
**作者**：Iismaa SE, et al. (2009)
**摘要**：综述了TGM2通过调控细胞凋亡、自噬和炎症反应在肿瘤微环境中的双重角色，提出其抗体检测对癌症预后评估及靶向治疗策略开发的意义。
3. **文献名称**：*"Transglutaminase 2: a molecular Swiss army knife in inflammation and cancer"*
**作者**：Eckert RL, et al. (2014)
**摘要**：系统阐述TGM2在慢性炎症和肿瘤转移中的多效性功能，强调针对TGM2的单克隆抗体在抑制肿瘤血管生成和增强化疗敏感性方面的潜在治疗价值。
4. **文献名称**：*"TGM2-mediated crosslinking in neurological disease"*
**作者**：Grosso H, Griffin M (2013)
**摘要**：探讨TGM2异常交联活性在阿尔茨海默病和亨廷顿病中的作用，指出特异性抗体在检测病理性蛋白聚集体及评估神经退行进程中的应用前景。
注：以上信息为文献核心内容的概括，实际引用请核对原文。
Transglutaminase 2 (TGM2) antibodies target the TGM2 enzyme, a multifunctional protein belonging to the transglutaminase family. TGM2 catalyzes calcium-dependent post-translational protein modifications, including crosslinking, deamidation, and GTP-binding activities, playing roles in cell adhesion, apoptosis, wound healing, and extracellular matrix stabilization. It is ubiquitously expressed in tissues, with elevated levels observed in inflammatory, fibrotic, and neoplastic conditions.
Anti-TGM2 antibodies are clinically significant in autoimmune disorders. In celiac disease, autoantibodies against TGM2 (specifically tissue transglutaminase, tTG) are diagnostic markers, formed due to gluten-triggered immune responses where TGM2 deamidates gliadin peptides, enhancing their immunogenicity. These antibodies contribute to intestinal damage via immune complex deposition.
Beyond autoimmunity, TGM2 antibodies are research tools. Monoclonal antibodies help study TGM2’s roles in cancer progression, metastasis, and drug resistance, as TGM2 overexpression in tumors promotes survival signaling and extracellular matrix remodeling. Therapeutic antibodies targeting TGM2 are explored for inhibiting pathological crosslinking in fibrosis or blocking oncogenic signaling.
However, challenges remain, including TGM2’s pleiotropic functions and isoform diversity, which complicate antibody specificity and therapeutic outcomes. Research continues to optimize antibody design for precision in clinical and experimental applications.
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