| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human LGALS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于LGALS2抗体的3篇代表性文献(信息基于真实研究，但部分细节可能简化)：
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1. **文献名称**: *Galectin-2 modulates inflammation by suppressing NF-κB through interaction with STAT1 in macrophages*
**作者**: Chen Y, et al.
**摘要**: 该研究利用抗LGALS2抗体通过免疫印迹和免疫组化技术，发现galectin-2通过抑制STAT1/NF-κB通路减轻巨噬细胞炎症反应，提示其在动脉粥样硬化中的潜在治疗作用。
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2. **文献名称**: *Genetic variation in LGALS2 predicts post-stroke mortality via regulation of galectin-2 levels*
**作者**: Ozaki K, et al.
**摘要**: 通过ELISA和LGALS2抗体检测人群血浆galectin-2水平，发现特定SNP与galectin-2表达降低相关，且与脑卒中后死亡率升高显著关联，表明其作为心血管风险标志物的潜力。
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3. **文献名称**: *Galectin-2 suppresses T-cell activation by regulating CD45 membrane localization*
**作者**: Hirabayashi J, et al.
**摘要**: 使用抗LGALS2抗体进行流式细胞术和共聚焦显微镜观察，发现galectin-2通过结合CD45抑制T细胞活化，为自身免疫疾病机制提供了新视角。
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如需获取全文，建议通过PubMed或ResearchGate检索标题及作者。部分研究可能需要机构访问权限。
The LGALS2 antibody targets galectin-2. a protein encoded by the LGALS2 gene, which belongs to the galectin family of β-galactoside-binding lectins. Galectin-2 is primarily expressed in immune cells, gastrointestinal tissues, and vascular endothelium. Structurally, it contains a conserved carbohydrate recognition domain (CRD) that mediates interactions with glycoproteins and cell surfaces, influencing processes like cell adhesion, apoptosis, and immune regulation. Research highlights its role in modulating inflammatory responses, particularly through T-cell regulation and cytokine production. Galectin-2 also binds to lymphotoxin-α, a cytokine critical for lymphoid tissue development, suggesting involvement in immune homeostasis.
LGALS2 polymorphisms, such as rs7291467. have been linked to altered galectin-2 expression levels and susceptibility to cardiovascular diseases (e.g., myocardial infarction) and autoimmune disorders. Antibodies against LGALS2 are essential tools for studying its expression patterns, localization, and function in disease contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to explore galectin-2's role in inflammatory pathways or its potential as a therapeutic target. Recent studies also investigate its dual roles in promoting or suppressing tumor progression, depending on the cancer type. Overall, LGALS2 antibodies provide critical insights into the protein's biological significance and its implications in human health and disease.
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