| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CT59; COXVIB2 |
| WB Predicted band size | 11 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human COX6B2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于COX6B2抗体的3篇文献摘要示例(注：COX6B2研究较少，部分文献可能基于推测或关联研究)：
1. **文献名称**：*Cytochrome c oxidase subunit 6B2 (COX6B2) is a biomarker for oxidative stress in human cancers*
**作者**：Smith A, et al.
**摘要**：本研究利用COX6B2特异性抗体，通过免疫组化分析发现其在肺癌组织中的表达显著上调，提示其可能作为氧化应激相关肿瘤的新型标志物。
2. **文献名称**：*Tissue-specific expression of COX6B2 in mammalian testis and its role in mitochondrial function*
**作者**：Zhang L, et al.
**摘要**：通过Western blot和免疫荧光技术，作者使用COX6B2抗体证实其在睾丸组织中的特异性高表达，并发现其缺失导致线粒体呼吸链功能异常。
3. **文献名称**：*Antibody-based profiling of COX6B2 in inflammatory bowel disease*
**作者**：Kim H, et al.
**摘要**：该研究开发了一种高特异性COX6B2单克隆抗体，用于检测结肠炎症组织中COX6B2的异常表达，揭示其与肠道屏障功能障碍的潜在关联。
**备注**：COX6B2的研究相对有限，上述文献为模拟示例，实际文献需通过PubMed或Web of Science以关键词“COX6B2 antibody”或“COX6B2 function”检索核实。
The COX6B2 antibody targets the cytochrome c oxidase subunit 6B2 (COX6B2), a nuclear-encoded subunit of mitochondrial complex IV (cytochrome c oxidase), a key component of the mitochondrial electron transport chain. COX6B2 is a testes-specific isoform of the COX6B subunit family, distinct from the ubiquitously expressed COX6B1. It localizes to the mitochondrial inner membrane and plays a role in energy metabolism and oxidative phosphorylation, particularly in sperm cell differentiation and male fertility.
COX6B2 antibodies are essential tools for studying tissue-specific mitochondrial function, reproductive biology, and metabolic disorders. They are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect COX6B2 expression patterns, primarily in testicular tissues or germ cells. Research involving these antibodies has highlighted COX6B2's association with male infertility, as its deficiency disrupts sperm motility and mitochondrial energetics.
Commercial COX6B2 antibodies are typically raised in rabbits or mice using peptide immunogens. Validation includes testing specificity via knockout controls or siRNA knockdown. Studies using these antibodies contribute to understanding mitochondrial dynamics, tissue-specific adaptations in energy metabolism, and molecular mechanisms underlying reproductive health.
×
