| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ANX8; CH17-360D5.2 |
| WB Predicted band size | 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ANXA8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及ANXA8抗体的文献摘要概览(文献信息为虚构示例，仅供格式参考)：
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1. **《ANXA8在乳腺癌中的差异表达及其临床意义》**
*作者：Smith J et al. (2020)*
摘要：本研究通过免疫组化(使用ANXA8特异性抗体)发现ANXA8在乳腺癌组织中高表达，且与肿瘤转移及患者预后不良显著相关，提示其可作为潜在生物标志物。
2. **《ANXA8调控细胞膜修复的分子机制》**
*作者：Lee S et al. (2018)*
摘要：利用ANXA8抗体进行蛋白质互作实验，揭示ANXA8通过与钙离子结合促进细胞膜损伤修复，为膜联蛋白家族功能提供了新证据。
3. **《ANXA8抗体在卵巢癌诊断中的优化应用》**
*作者：Zhang R et al. (2021)*
摘要：开发了一种高灵敏度的ANXA8单克隆抗体，验证其在卵巢癌血清检测中的特异性，为无创诊断提供了新工具。
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注：实际文献需通过PubMed或Google Scholar检索关键词“ANXA8 antibody”获取。建议使用权威数据库核实具体研究。
The ANXA8 antibody targets Annexin A8 (ANXA8), a member of the annexin family of calcium-dependent phospholipid-binding proteins. Annexins are involved in diverse cellular processes, including membrane organization, vesicle trafficking, and signal transduction. ANXA8. specifically, contains four conserved annexin repeats and exhibits calcium-dependent binding to phospholipid membranes. It is expressed in various tissues, with notable presence in the placenta, kidneys, and immune cells. Unlike other annexins, ANXA8 shows restricted expression patterns, suggesting specialized roles in specific cell types or developmental stages.
Functionally, ANXA8 has been implicated in regulating membrane dynamics during exocytosis and endocytosis, as well as modulating intracellular calcium signaling. Studies link it to cell proliferation, differentiation, and apoptosis. Its overexpression has been observed in certain cancers, including breast, ovarian, and pancreatic carcinomas, where it may contribute to tumor progression by enhancing cell survival and invasiveness. In renal physiology, ANXA8 is associated with podocyte function and glomerular filtration, with altered expression noted in kidney diseases like focal segmental glomerulosclerosis.
ANXA8 antibodies are critical tools for detecting the protein’s expression and localization in research and diagnostics. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its role in disease mechanisms or normal physiology. Recent investigations also explore ANXA8 as a potential biomarker or therapeutic target, particularly in oncology. However, its precise molecular mechanisms and interactions remain under active investigation, highlighting the need for high-specificity antibodies to advance functional and clinical studies.
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