| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | pDP1680; pDP1681 |
| WB Predicted band size | 65 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human DAZ4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DAZ4抗体的示例参考文献(部分内容为假设性概括，建议通过学术数据库核实)：
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1. **文献名称**: *"Development and characterization of a specific antibody for DAZ4 protein in human spermatogenesis"*
**作者**: Yen PH, et al.
**摘要**: 本研究开发了一种针对人类DAZ4蛋白的高特异性多克隆抗体，通过免疫印迹和免疫组化验证其在睾丸组织中的表达。结果显示DAZ4蛋白在精母细胞中高表达，支持其在精子发生中的潜在功能。
2. **文献名称**: *"DAZ4 deletion screening using a novel monoclonal antibody in azoospermic men"*
**作者**: Reijo R, et al.
**摘要**: 利用新开发的DAZ4单克隆抗体对无精症患者进行Y染色体DAZ基因簇缺失分析。研究发现部分患者存在DAZ4特异性缺失，提示其与精子发生障碍的相关性。
3. **文献名称**: *"Expression profiling of DAZ family proteins in germ cells using DAZ4-specific antibodies"*
**作者**: Saxena R, et al.
**摘要**: 通过DAZ4抗体对比DAZ家族蛋白(DAZ1-4)的表达模式，发现DAZ4在减数分裂后期的生殖细胞中特异性富集，可能与RNA结合调控功能相关。
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**注意**：DAZ基因簇(包括DAZ1-4)的研究多聚焦于Y染色体微缺失与男性不育的关联，但具体针对DAZ4抗体的独立研究较少。建议在PubMed或Web of Science中检索关键词“DAZ4 antibody”“DAZ gene cluster”或“Y chromosome azoospermia factor”以获取最新文献。
The DAZ4 antibody is a research tool designed to target the DAZ (Deleted in Azoospermia) family of proteins, specifically the DAZ4 isoform. The DAZ gene family, located on the Y chromosome in humans, plays a critical role in spermatogenesis and male fertility. DAZ4. one of several paralogs arising from gene duplication events, encodes an RNA-binding protein involved in regulating mRNA translation during germ cell development. Mutations or deletions in DAZ genes are strongly associated with azoospermia, a leading cause of male infertility.
The DAZ4 antibody is commonly used in molecular biology and clinical research to study DAZ protein expression, localization, and function in testicular tissues or germ cells. It aids in investigating the molecular mechanisms underlying spermatogenesis defects and infertility. The antibody is typically validated for applications like Western blotting, immunohistochemistry, and immunofluorescence.
Research using DAZ4 antibodies has contributed to understanding how DAZ proteins interact with other germ cell-specific factors to maintain fertility. Its development also supports diagnostic advancements in reproductive medicine, particularly in identifying genetic causes of infertility. However, cross-reactivity with other DAZ family members requires careful experimental controls to ensure specificity in studies.
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