| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN |
| WB Predicted band size | 70 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human LCP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ETV1抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **文献名称**：*Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer*
**作者**：Tomlins SA, et al.
**摘要**：该研究首次报道了前列腺癌中TMPRSS2与ETS家族基因(包括ETV1)的融合现象，并通过ETV1抗体的免疫组化实验证实了ETV1蛋白在前列腺癌细胞中的异常高表达，提示其作为致癌驱动因子的作用。
2. **文献名称**：*ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours*
**作者**：Chi P, et al.
**摘要**：本研究揭示ETV1在胃肠道间质瘤(GIST)中的关键作用，通过ETV1抗体的染色实验发现其与KIT信号通路协同促进肿瘤发生，且ETV1表达水平与患者预后相关，为靶向治疗提供了依据。
3. **文献名称**：*Differential expression of ETV1 and its roles in melanoma progression*
**作者**：Jane-Valbuena J, et al.
**摘要**：文章利用ETV1抗体的Western blot和免疫荧光技术，分析了ETV1在黑色素瘤不同阶段的表达差异，发现其高表达与肿瘤侵袭性增强和转移相关，提示其可作为潜在生物标志物。
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以上文献均以ETV1抗体为核心实验工具，聚焦于不同癌症中ETV1的功能研究。如需更多文献或扩展内容，请进一步说明需求。
The ETV1 antibody is a crucial tool in studying the ETS translocation variant 1 (ETV1) protein, a member of the ETS family of transcription factors. ETV1 regulates gene expression by binding to DNA through its conserved ETS domain and plays roles in cellular processes such as proliferation, differentiation, and apoptosis. It is activated by signaling pathways like MAPK/ERK and is implicated in cancer development when dysregulated. For example, ETV1 overexpression or chromosomal translocations (e.g., TMPRSS2-ETV1 in prostate cancer) drive oncogenesis by promoting cell survival, invasion, and metastasis. ETV1 is also linked to gastrointestinal stromal tumors (GISTs) and melanoma.
ETV1 antibodies are widely used in research to detect ETV1 expression and localization via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help identify ETV1's role in tumor progression, its interaction with signaling pathways, and its potential as a therapeutic target or biomarker. In diagnostics, ETV1 antibodies aid in classifying cancers with ETV1 alterations, guiding personalized treatment strategies. However, challenges remain in ensuring antibody specificity due to structural similarities among ETS family members. Ongoing research focuses on refining antibody validation and exploring ETV1's therapeutic modulation in precision oncology.
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