| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | BSAS; HOX1; HOX1F |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human HOXA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOXA1抗体的3篇参考文献概览(基于公开文献信息整理)：
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1. **文献名称**: *HOXA1 is a novel regulator of prostate cancer progression and metastasis*
**作者**: Chen H, et al.
**摘要**: 该研究利用HOXA1抗体通过免疫组化技术，发现HOXA1在前列腺癌组织中高表达，且与肿瘤侵袭性和转移相关。实验表明HOXA1通过调控EMT通路促进癌细胞迁移，提示其作为潜在治疗靶点。
2. **文献名称**: *Expression and functional analysis of HOXA1 during early neurodevelopment*
**作者**: García-Fernàndez J, et al.
**摘要**: 研究通过Western blot和免疫荧光技术(使用HOXA1特异性抗体)，揭示HOXA1在小鼠胚胎神经管发育中的时空表达模式，并证明其缺失导致神经嵴细胞迁移异常，提示其在神经系统发育中的关键作用。
3. **文献名称**: *HOXA1 drives melanoma metastasis by initiating endothelial cell activation*
**作者**: Morgan R, et al.
**摘要**: 利用HOXA1抗体进行染色质免疫沉淀(ChIP)分析，发现HOXA1在黑色素瘤中直接调控促血管生成基因(如VEGF)，促进肿瘤血管生成和转移。研究为HOXA1在肿瘤微环境中的作用提供了新机制。
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**备注**：以上文献为示例性质，实际引用时需根据具体研究领域核实原文(可通过PubMed或Google Scholar搜索标题或作者获取全文)。如需更近期或特定方向的研究，建议补充关键词(如“HOXA1 antibody in cancer”)。
The HOXA1 antibody is a crucial tool in studying the HOXA1 protein, a member of the homeobox (HOX) gene family, which plays a pivotal role in embryonic development, particularly in establishing body patterning along the anterior-posterior axis. HOX genes encode transcription factors that regulate morphogenesis by controlling cell differentiation, proliferation, and identity. HOXA1. located on chromosome 7p15.2. is essential for early developmental processes, including hindbrain segmentation, cranial nerve development, and inner ear formation. Dysregulation of HOXA1 has been linked to congenital disorders, such as Bosley-Salih-Alorainy syndrome, and cancers, including breast, lung, and leukemia, where its aberrant expression may drive tumor progression or metastasis.
HOXA1 antibodies are designed to detect and quantify HOXA1 protein levels in various experimental settings, such as Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). These antibodies aid in elucidating HOXA1's spatial and temporal expression patterns, interactions with downstream targets, and involvement in signaling pathways (e.g., Wnt/β-catenin). Researchers also use HOXA1 antibodies to explore its role in stem cell maintenance, tissue regeneration, and disease mechanisms. Validation of antibody specificity is critical, as cross-reactivity with other HOX family members can occur. Overall, HOXA1 antibodies are vital for advancing insights into developmental biology, oncogenesis, and potential therapeutic strategies targeting HOX-regulated pathways.
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