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Rabbit Polyclonal PEX14 Antibody

  • 中文名： PEX14抗体
  • 别    名： NAPP2; PBD13A; Pex14p; dJ734G22.2
货号: IPDX13785
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesNAPP2; PBD13A; Pex14p; dJ734G22.2
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human PEX14
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于PEX14抗体的参考文献示例(文献信息为模拟生成，仅供参考)：

1. **文献名称**: "PEX14 interacts with PEX5 and regulates peroxisomal protein import"

**作者**: Smith A, et al.

**摘要**: 该研究利用PEX14抗体通过免疫共沉淀和免疫荧光技术，揭示了PEX14与PEX5在过氧化物酶体蛋白转运中的直接相互作用，证实其在膜蛋白复合物组装中的关键作用。

2. **文献名称**: "Structural analysis of human PEX14 reveals a flexible domain essential for peroxisomal biogenesis"

**作者**: Tanaka K, et al.

**摘要**: 通过Western blot和免疫电镜技术，使用PEX14抗体解析了人源PEX14的N端结构域构象，发现其柔性结构对PEX5的结合及过氧化物酶体膜的形成至关重要。

3. **文献名称**: "PEX14 deficiency in mice causes peroxisomal dysfunction and neurodegeneration"

**作者**: Chen L, et al.

**摘要**: 利用PEX14抗体检测基因敲除小鼠模型中的蛋白表达缺失，发现PEX14缺陷导致过氧化物酶体功能异常及神经元退行性病变，提示其与相关遗传疾病的关联。

4. **文献名称**: "PEX14 as a host factor for viral infection: Antibody-based inhibition studies"

**作者**: Wang Y, et al.

**摘要**: 通过抗PEX14的中和抗体阻断实验，证明宿主细胞PEX14蛋白参与某些RNA病毒(如HCV)的复制过程，为抗病毒治疗提供新靶点。

(注：以上文献为示例，实际引用需查询PubMed等数据库获取真实信息。)

背景信息

PEX14 antibodies are essential tools for studying peroxisome biology, targeting the PEX14 protein—a critical component of the peroxisomal membrane. Peroxisomes are organelles involved in lipid metabolism, reactive oxygen species detoxification, and bile acid synthesis. PEX14 plays a central role in peroxisome biogenesis by acting as a docking receptor for cytosolic PEX5. which transports matrix proteins containing a peroxisomal targeting signal (PTS1). This interaction facilitates the import of cargo proteins into the peroxisomal matrix. Antibodies against PEX14 are widely used to investigate peroxisome dynamics, dysfunction, or proliferation in various diseases, including peroxisomal disorders (e.g., Zellweger syndrome), neurodegenerative conditions, and metabolic syndromes. They enable detection of PEX14 expression levels, subcellular localization (via immunofluorescence or immunoelectron microscopy), and protein-protein interactions (via co-immunoprecipitation). Available as monoclonal or polyclonal variants, these antibodies are typically validated in assays like Western blotting, immunohistochemistry, or knockout cell line controls. Research applications also extend to studying crosstalk between peroxisomes and other organelles, such as mitochondria or the endoplasmic reticulum, highlighting PEX14's role in cellular homeostasis. Reliable PEX14 antibodies are crucial for advancing understanding of peroxisome-related pathologies and therapeutic strategies.

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