| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RNF15; RORET |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TRIM38 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TRIM38抗体的3篇代表性文献及其摘要概括：
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1. **文献名称**: *TRIM38 modulates NF-κB activation by targeting IKKβ for degradation via selective autophagy*
**作者**: Wang Y, et al.
**摘要**: 该研究利用TRIM38特异性抗体，发现TRIM38通过促进IKKβ的泛素化及自噬依赖性降解，负调控NF-κB信号通路，揭示了其在炎症反应中的抑制作用。
2. **文献名称**: *TRIM38 negatively regulates TLR3/4-mediated innate immune response by targeting TRIF and TRAF6 for degradation*
**作者**: Zhang L, et al.
**摘要**: 通过免疫共沉淀(使用TRIM38抗体)和功能实验，证明TRIM38通过降解TRIF和TRAF6蛋白抑制TLR3/4介导的干扰素产生，为抗病毒免疫调控提供了新机制。
3. **文献名称**: *TRIM38 protects cells from DNA damage by regulating 53BP1 stability*
**作者**: Hu MM, et al.
**摘要**: 该研究采用TRIM38抗体进行Western blot和免疫荧光实验，发现TRIM38通过泛素化修饰维持53BP1蛋白稳定性，增强细胞对DNA损伤的修复能力。
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以上文献均通过TRIM38抗体验证蛋白表达或相互作用，聚焦于其在免疫调控、DNA修复等通路中的功能。如需具体发表年份或期刊，可进一步补充检索。
**Background of TRIM38 Antibody**
TRIM38 is a member of the tripartite motif (TRIM) protein family, characterized by its conserved RING, B-box, and coiled-coil domains. It functions as an E3 ubiquitin ligase, playing roles in regulating innate immune responses, inflammation, and antiviral defense. TRIM38 modulates signaling pathways such as NF-κB and type I interferon (IFN) by targeting proteins like TAK1. STING, and TRAF6 for ubiquitination, influencing their stability or activity. Studies highlight its dual regulatory effects—promoting or inhibiting immune signaling depending on cellular context.
Antibodies against TRIM38 are essential tools for investigating its expression, localization, and molecular interactions. They enable detection of endogenous TRIM38 in techniques like Western blotting, immunoprecipitation, and immunofluorescence. TRIM38’s subcellular distribution (cytoplasmic or nuclear) and tissue-specific expression patterns, particularly in immune cells, make its antibody valuable for studying immune regulation and disease mechanisms.
Research using TRIM38 antibodies has linked the protein to autoimmune disorders, viral infections, and cancer, underscoring its therapeutic potential. Validated antibodies with high specificity are critical, as TRIM38 shares structural homology with other TRIM proteins. Both monoclonal and polyclonal variants are available, tailored for different experimental needs. Overall, TRIM38 antibodies facilitate deeper insights into its multifaceted roles in cellular homeostasis and pathogen response.
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