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Rabbit Polyclonal KRTAP1-1 Antibody

  • 中文名: KRTAP1-1抗体
  • 别    名: HB2A; KAP1.1; KAP1.6; KAP1.7; KAP1.1A; KAP1.1B; KRTAP1A; hKAP1.7; KRTAP1.1
货号: IPDX13741
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/50 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/500-1/1000 Human,Mouse,Rat

产品详情

AliasesHB2A; KAP1.1; KAP1.6; KAP1.7; KAP1.1A; KAP1.1B; KRTAP1A; hKAP1.7; KRTAP1.1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human KRTAP1-1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3条关于KRTAP1-1抗体的参考文献示例(注:部分文献信息为示例性虚构,实际引用时请核实真实来源):

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1. **文献名称**: "Characterization of KRTAP1-1 Antibody for Hair Keratin Analysis"

**作者**: Smith J, et al.

**摘要**: 本研究开发了针对KRTAP1-1蛋白的多克隆抗体,验证了其在人类毛囊角蛋白相关蛋白中的特异性结合能力,并用于分析KRTAP1-1在毛发纤维形成中的分子作用。

2. **文献名称**: "Expression Profiling of KRTAP1-1 in Human Skin Tissues Using Monoclonal Antibodies"

**作者**: Lee H, et al.

**摘要**: 通过制备KRTAP1-1单克隆抗体,揭示了该蛋白在表皮角质细胞中的差异性表达模式,并发现其与表皮屏障功能的相关性。

3. **文献名称**: "KRTAP1-1 as a Potential Biomarker in Alopecia: Antibody-Based Detection"

**作者**: Zhang R, et al.

**摘要**: 利用KRTAP1-1特异性抗体,发现斑秃患者毛囊中KRTAP1-1的表达显著下调,提示其在毛发疾病诊断中的潜在应用价值。

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**说明**:以上文献为示例性内容,实际研究中请通过PubMed或Web of Science等平台检索真实文献(关键词:KRTAP1-1 antibody, keratin-associated protein)。KRTAP1-1属于角蛋白相关蛋白家族,相关研究多集中于毛发结构、皮肤疾病及遗传变异分析。

背景信息

The KRTAP1-1 antibody targets keratin-associated protein 1-1 (KRTAP1-1), a member of the keratin-associated protein (KAP) family. KAPs are structural components of hair and skin, forming a matrix that cross-links keratin intermediate filaments to enhance mechanical strength and stability. KRTAP1-1. encoded by the *KRTAP1-1* gene on chromosome 17q12-q21. is primarily expressed in hair follicles and contributes to hair shaft formation. Its cysteine-rich domains facilitate disulfide bonds, critical for hair fiber integrity. Antibodies against KRTAP1-1 are valuable tools for studying hair biology, genetic disorders (e.g., monilethrix or hypotrichosis), and keratin-related pathologies. They enable localization of KRTAP1-1 in tissues via immunohistochemistry, quantify expression levels via Western blotting or ELISA, and aid in exploring gene regulation and protein interactions. Commercial KRTAP1-1 antibodies are typically developed in rabbits or mice using recombinant protein or peptide immunogens. Validation includes specificity testing in knockout models or siRNA-treated cells. Research using these antibodies has advanced understanding of hair follicle development, cycling, and diseases linked to KAP dysregulation, offering potential insights into therapeutic strategies for hair and skin disorders.

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