Rabbit Polyclonal INO80 Antibody

The INO80 antibody is a research tool designed to target the INO80 chromatin remodeling complex, a conserved multi-subunit protein assembly critical for genome regulation. Named after its catalytic subunit (INO80), this complex belongs to the SWI/SNF2 family of ATP-dependent chromatin remodelers. It plays key roles in DNA repair, replication, transcription regulation, and histone variant exchange (e.g., H2A.Z deposition). The INO80 complex contains distinct structural domains, including helicase-like modules and actin-related proteins (ARPs), enabling nucleosome repositioning and chromatin structure modulation. Antibodies against INO80 are widely used in techniques like Western blotting, immunoprecipitation (IP), and chromatin immunoprecipitation (ChIP-seq) to study its localization, interactions, and role in epigenetic mechanisms. Researchers employ these antibodies to investigate INO80's involvement in maintaining genomic stability, resolving replication stress, and regulating gene expression programs. Dysregulation of INO80 has been linked to cancers and developmental disorders, making its study clinically relevant. Validated INO80 antibodies help elucidate how chromatin remodeling impacts cellular responses to DNA damage, stem cell differentiation, and metabolic signaling pathways. Proper antibody validation (e.g., knockout controls) is essential due to potential cross-reactivity with related complexes like SWR1.