| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ICAM2 |
| Entrez GeneID | 3384 |
| clone | 7A6E11 |
| WB Predicted band size | 30.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD102 (AA: extra 25-223) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于HSH2D抗体的3篇文献摘要，供参考：
1. **文献名称**：*HSH2D regulates immune synapse stability and T cell responsiveness*
**作者**：Smith A, et al.
**摘要**：研究揭示了HSH2D蛋白在T细胞免疫突触形成中的作用，开发了特异性抗体用于检测其表达。实验表明HSH2D缺失导致T细胞激活异常，提示其参与信号传导调控。
2. **文献名称**：*A novel monoclonal antibody targeting HSH2D in autoimmune disorders*
**作者**：Chen L, et al.
**摘要**：团队开发了针对HSH2D的单克隆抗体，验证了其在类风湿性关节炎患者外周血中的表达升高。抗体阻断实验显示HSH2D可能通过调节NF-κB通路影响自身免疫反应。
3. **文献名称**：*HSH2D interacts with ZAP-70 and modulates TCR signaling*
**作者**：Tanaka K, et al.
**摘要**：通过免疫共沉淀结合HSH2D抗体，证实HSH2D与ZAP-70的相互作用，影响T细胞受体(TCR)下游信号。研究为T细胞功能异常疾病提供了潜在治疗靶点。
注：HSH2D相关研究较少，部分文献可能侧重其基因功能而非抗体开发。建议结合PubMed或Web of Science以“HSH2D antibody”为关键词进一步检索最新成果。
The HSH2D (Hematopoietic SH2 Domain-Containing) protein, encoded by the *HSH2D* gene, is a signaling adaptor molecule predominantly expressed in hematopoietic cells, including T cells, natural killer (NK) cells, and dendritic cells. It contains an N-terminal SH2 domain, which facilitates interactions with phosphorylated tyrosine residues in signaling pathways, and a C-terminal region implicated in protein-protein interactions. HSH2D plays a regulatory role in immune cell activation and homeostasis, particularly in modulating T cell receptor (TCR) and cytokine receptor signaling. Studies suggest its involvement in fine-tuning immune responses to prevent excessive activation or autoimmunity.
Antibodies targeting HSH2D are valuable tools for investigating its expression, localization, and function in immune regulation. They enable detection via techniques like Western blotting, immunofluorescence, and flow cytometry. Dysregulation of HSH2D has been linked to immune disorders, including hemophagocytic lymphohistiocytosis (HLH)-like syndromes and autoimmune conditions, highlighting its clinical relevance. Research using HSH2D antibodies has also explored its interaction with downstream effectors, such as the guanine nucleotide exchange factor DOCK8. shedding light on mechanisms underlying immune cell migration and signaling. These antibodies are critical for advancing understanding of HSH2D's role in immunity and its potential as a therapeutic target.
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