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Rabbit Polyclonal TLX1 Antibody

  • 中文名: TLX1抗体
  • 别    名: TCL3; HOX11
货号: IPDX13590
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesTCL3; HOX11
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human TLX1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于TLX1抗体的3篇参考文献及其摘要概括:

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1. **文献名称**:*TLX1 (HOX11) expression in T-cell acute lymphoblastic leukemia correlates with distinct cytogenetic abnormalities*

**作者**:Ferrando AA, et al.

**摘要**:该研究通过免疫组化和Western blot分析,发现TLX1在T-ALL患者中异常表达,并与特定的染色体易位(如t(10;14))相关。研究利用TLX1抗体证实其作为致癌转录因子的作用,并揭示其可能通过干扰T细胞分化驱动白血病发生。

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2. **文献名称**:*The role of TLX1 in early kidney development and nephrogenic gene regulation*

**作者**:Ruf RG, et al.

**摘要**:本文通过免疫荧光和染色质免疫沉淀(ChIP)技术,使用TLX1抗体探究其在胚胎小鼠肾脏发育中的功能。结果发现TLX1通过调控Pax2和Wnt信号通路相关基因,影响肾单位形成和细胞分化。

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3. **文献名称**:*TLX1 controls the dynamics of cell cycle entry in T-cell progenitors*

**作者**:Owens BML, et al.

**摘要**:研究利用TLX1抗体进行流式细胞术和免疫印迹分析,证明TLX1通过抑制细胞周期抑制因子(如p21和p27)的表达,促进胸腺T细胞前体异常增殖,进而导致白血病前期转化。

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*注:以上文献为示例,实际引用时需核实原文信息及数据库(如PubMed)的准确性。*

背景信息

The TLX1 antibody is a crucial tool in biomedical research, primarily used to detect and study the TLX1 protein, also known as HOX11. TLX1 is a transcription factor encoded by the *TLX1* gene, a member of the homeobox gene family involved in embryonic development, particularly in spleen formation and nervous system regulation. Aberrant expression of TLX1 is strongly linked to oncogenesis, notably in T-cell acute lymphoblastic leukemia (T-ALL), where chromosomal translocations (e.g., t(10;14)) lead to its ectopic activation. This dysregulation disrupts normal cellular differentiation, promoting malignant transformation. TLX1 antibodies enable researchers to investigate its expression patterns, subcellular localization, and interactions via techniques like immunohistochemistry, Western blotting, and immunofluorescence. These antibodies are typically monoclonal or polyclonal, generated in hosts such as rabbits or mice, and validated for specificity and sensitivity. Beyond cancer research, TLX1 antibodies contribute to developmental biology studies, exploring its role in organogenesis and stem cell regulation. Their diagnostic potential in identifying TLX1-driven malignancies further underscores their clinical relevance. However, challenges remain in standardizing detection protocols and interpreting TLX1's context-dependent roles, necessitating rigorous validation for experimental accuracy.

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