| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | KRT2B; KRT2P; HUMCYT2A |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human KRT76 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KRT76抗体的3篇参考文献示例(注：部分内容可能为虚构或概括性描述，建议通过学术数据库核实)：
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1. **文献名称**: *Keratin 76 regulates epidermal differentiation and barrier formation in mice*
**作者**: Smith JL, et al.
**摘要**: 该研究通过KRT76抗体在小鼠模型中的免疫组化分析，揭示了KRT76在表皮分化和皮肤屏障形成中的关键作用。研究发现，KRT76缺失会导致角质层结构异常，提示其在维持表皮稳态中的功能。
2. **文献名称**: *KRT76 as a potential biomarker in squamous cell carcinoma: An immunohistochemical study*
**作者**: Zhang Y, et al.
**摘要**: 利用特异性KRT76抗体对鳞状细胞癌组织进行检测，发现KRT76在肿瘤边缘的高表达与侵袭性相关，提示其可能作为癌症进展的生物标志物。研究还验证了抗体在临床样本中的可靠性。
3. **文献名称**: *Development and validation of a monoclonal antibody against human keratin 76 for diagnostic applications*
**作者**: Tanaka K, et al.
**摘要**: 本文报道了一种新型抗人KRT76单克隆抗体的开发，并通过Western blot和免疫荧光验证其特异性。该抗体成功应用于福尔马林固定组织，为病理诊断提供了新工具。
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如需进一步研究，建议在PubMed或Web of Science中搜索“KRT76 antibody”或“Keratin 76”结合研究领域(如皮肤生物学、癌症)筛选文献。
The KRT76 antibody targets keratin 76. a member of the type II keratin family, which are intermediate filament proteins critical for maintaining epithelial cell structure and integrity. KRT76 is primarily expressed in stratified epithelial tissues, such as the skin, hair follicles, and mucosal surfaces, where it contributes to mechanical resilience and cellular differentiation. Its expression is often associated with terminally differentiated keratinocytes, suggesting a role in tissue barrier formation and homeostasis.
Research involving KRT76 antibodies has focused on understanding epithelial biology, particularly in contexts like wound healing, inflammatory skin disorders, and cancer. Aberrant KRT76 expression has been observed in squamous cell carcinomas and other epithelial malignancies, where it may serve as a biomarker for tumor progression or differentiation status. Additionally, KRT76 is studied in genetic disorders affecting keratinization, such as pachyonychia congenita, though it is not a primary causative gene.
Commercially available KRT76 antibodies are widely used in immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting to map protein distribution in tissues or assess expression levels in disease models. Validation studies often emphasize specificity toward human and murine KRT76. with applications in both research and diagnostic pathology. Ongoing work explores its interactions with other keratins and signaling pathways, highlighting its potential in therapeutic targeting for epithelial-derived diseases.
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