| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human HLA-DRB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下为3篇关于HLA-DRB1抗体的代表性文献摘要：
1. **《HLA-DRB1 antibody-mediated rejection in kidney transplantation》**
- 作者：Sapir-Pichhadze R, et al.
- 摘要：探讨HLA-DRB1抗体在肾移植排斥反应中的作用，发现其与移植物功能减退和慢性排斥显著相关，提示术前抗体筛查对预后评估的重要性。
2. **《Anti-HLA-DRB1 antibodies as biomarkers for rheumatoid arthritis susceptibility》**
- 作者：Raychaudhuri S, et al.
- 摘要：通过GWAS分析揭示特定HLA-DRB1表位抗体与类风湿性关节炎的遗传关联，为疾病早期诊断提供血清学标志物依据。
3. **《HLA-DRB1 epitope-specific antibody profiling in transplant recipients》**
- 作者：Tait BD, et al.
- 摘要：开发基于Luminex的HLA-DRB1表位分型技术，证明高分辨率抗体检测可优化器官分配策略并降低移植后排斥风险。
注：以上文献为示例性质，实际引用时建议通过PubMed/Google Scholar以"HLA-DRB1 antibody"+"transplant"/"autoimmunity"等关键词检索最新研究。近5年研究多聚焦于表位解析和临床检测标准化(如2021年《American Journal of Transplantation》相关综述)。
HLA-DRB1 antibodies target specific epitopes of the HLA-DRB1 molecule, a class II human leukocyte antigen (HLA) encoded by the major histocompatibility complex (MHC). These antibodies are clinically significant in transplantation and autoimmune diseases. HLA-DRB1 molecules are expressed on antigen-presenting cells and play a central role in immune recognition by presenting exogenous peptides to CD4+ T cells. Their high polymorphism (over 1.000 known alleles) contributes to individual immune diversity but also increases the risk of alloimmunization.
In transplantation, HLA-DRB1 antibodies are associated with graft rejection, particularly in kidney and hematopoietic stem cell transplants. They may develop through prior exposure (pregnancy, transfusions, or previous transplants) or de novo post-transplant. Detection via solid-phase assays (e.g., single-antigen bead tests) helps assess donor compatibility and guide desensitization protocols.
Autoimmune links are also notable. Certain HLA-DRB1 alleles (*04:01. *04:04. *04:05) show strong associations with rheumatoid arthritis, while specific antibody profiles may influence disease severity. In transfusion medicine, these antibodies can cause platelet refractoriness or transfusion-related lung injury (TRALI).
Clinical management involves antibody monitoring, immunosuppression, and personalized HLA matching to mitigate immune complications.
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