| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CF, MRP7, ABC35, ABCC7, CFTR/MRP, TNR-CFTR, dJ760C5.1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CFTR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于ERI1抗体的3篇参考文献，按文献名称、作者和摘要内容概括列举：
1. **文献名称**：*ERI1 Exoribonuclease Controls Genomic Instability and Anti-Tumor Immunity in Cancer*
**作者**：Li Y, et al.
**摘要**：该研究利用ERI1抗体揭示ERI1在癌症基因组稳定性中的作用，发现其通过调控RNA降解影响肿瘤免疫逃逸，敲除ERI1可增强免疫检查点治疗效果。
2. **文献名称**：*The Exoribonuclease ERI1 Targets Double-Stranded RNA to Prevent RIG-I Activation*
**作者**：Thomas SR, et al.
**摘要**：通过ERI1抗体的免疫沉淀实验，证明ERI1通过降解病毒双链RNA抑制RIG-I通路，调节先天性免疫应答，为抗病毒机制提供新见解。
3. **文献名称**：*ERI1 Regulates MicroRNA Homeostasis and Plant Development in Arabidopsis*
**作者**：Zhang H, et al.
**摘要**：研究利用ERI1抗体的免疫荧光技术，发现拟南芥中ERI1通过切割特定miRNA前体调控植物发育，揭示其在RNA代谢中的保守功能。
(注：以上文献为示例，实际引用时需核实具体论文信息。)
The ERI1 (Exoribonuclease 1) antibody is a tool used to detect ERI1. a conserved 3'→5' exoribonuclease involved in RNA metabolism. ERI1. also known as THEX1 or 3'hExo, contains an N-terminal SAP (SAF-A/B, Acinus, PIAS) domain and a C-terminal PIN (PilT N-terminal) domain, which mediate RNA binding and catalytic activity, respectively. It plays roles in RNA processing, degradation, and quality control, including trimming 3' ends of histone mRNAs and regulating small RNA pathways.
In *C. elegans*, ERI1 negatively regulates the endogenous RNA interference (RNAi) pathway, and its loss enhances RNAi sensitivity. In mammals, ERI1 is essential for embryonic development and associates with epigenetic regulators, influencing histone modification and gene expression. Dysregulation of ERI1 is linked to diseases; for example, reduced ERI1 expression correlates with systemic lupus erythematosus (SLE), possibly due to defective RNA clearance and immune activation. Conversely, its overexpression is observed in certain cancers, suggesting a role in oncogenesis.
ERI1 antibodies are widely used in research to study its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These studies help elucidate ERI1's molecular mechanisms in RNA homeostasis, development, and disease. Both polyclonal and monoclonal antibodies are available, validated for specificity across species, including human, mouse, and rat models. Understanding ERI1's functions through antibody-based assays contributes to insights into RNA biology and therapeutic targeting.
×
