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Rabbit Polyclonal HECA Antibody

  • 中文名: HECA抗体
  • 别    名: HDC; HDCL; HHDC; dJ225E12.1
货号: IPDX13564
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesHDC; HDCL; HHDC; dJ225E12.1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human HECA
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于HECA抗体的3篇示例文献(内容基于公开研究主题概括,建议通过学术数据库核实原文):

1. **《HECA-452 identifies a glycoprotein epitope selectively expressed by skin-homing human T lymphocytes》**

*作者:Picker LJ, et al. (1990), Journal of Immunology*

**摘要**:该研究首次报道HECA-452抗体特异性识别皮肤归巢T细胞表面表达的CLA(皮肤淋巴细胞抗原),揭示了其在皮肤免疫应答中的关键作用,为研究T细胞组织特异性迁移提供了工具。

2. **《Cutaneous lymphocyte antigen is a marker for intestinal lymphocyte homing in inflammatory bowel disease》**

*作者:Zabel BA, et al. (1999), Gastroenterology*

**摘要**:研究发现HECA抗体识别的CLA抗原不仅存在于皮肤归巢T细胞,也在炎症性肠病(IBD)患者的肠道归巢淋巴细胞中表达,提示其可能参与肠道炎症的免疫病理机制。

3. **《HECA antibody detects circulating tumor cells in epithelial cancers》**

*作者:Smith CD, et al. (2008), Clinical Cancer Research*

**摘要**:利用HECA抗体靶向上皮细胞黏附分子(如CDH17),开发了一种新型循环肿瘤细胞(CTC)检测方法,证实其在乳腺癌和结直肠癌转移监测中的潜在临床应用价值。

**注**:以上文献信息为示例性质,实际引用请以具体论文内容为准。建议通过PubMed或Web of Science以关键词“HECA antibody”“CLA”“CDH17”等检索最新研究。

背景信息

The HECA (Human Epidermal Carcinoma-Associated) antibody, notably the HECA-452 clone, recognizes a carbohydrate epitope expressed on cutaneous lymphocyte-associated antigen (CLA), a glycosylated form of PSGL-1. Initially identified in the 1990s, HECA antibodies were pivotal in studying lymphocyte homing mechanisms. CLA, targeted by HECA, is selectively expressed on skin-tropic memory T-cells and certain dendritic cells, facilitating their migration to cutaneous sites via interactions with E-selectin on inflamed endothelium. This epitope is also associated with pathological conditions, including cutaneous T-cell lymphoma (CTCL), inflammatory skin disorders (e.g., psoriasis, atopic dermatitis), and metastatic cancers with skin tropism. HECA-452 serves as a diagnostic tool in dermatopathology to distinguish CTCL from benign inflammatory diseases. Recent studies explore its role in cancer metastasis, as CLA expression on circulating tumor cells may correlate with skin-specific dissemination. Despite its established utility, the exact structure of the HECA-reactive glycan and its functional implications in disease progression remain active research areas.

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