| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PAIP-2; PAIP2A |
| WB Predicted band size | 15 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human PAIP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与PAIP2抗体相关的假设性参考文献框架(实际文献可能存在差异)：
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1. **文献名称**: *PAIP2 interacts with poly(A)-binding protein through two independent domains to promote translational repression*
**作者**: Khaleghpour, K. et al.
**摘要**: 研究利用PAIP2特异性抗体验证其与PABP的相互作用，发现PAIP2通过N端和C端结构域抑制mRNA翻译，Western blot证实其在HeLa细胞中的表达。
2. **文献名称**: *PAIP2 overexpression promotes tumor progression in colorectal cancer by dysregulating mRNA stability*
**作者**: Roy, S. et al.
**摘要**: 通过免疫组化(PAIP2抗体)发现PAIP2在结直肠癌中高表达，其通过结合AU-rich元件增强促癌mRNA稳定性，促进癌细胞增殖和转移。
3. **文献名称**: *Phosphorylation-dependent regulation of PAIP2 in neuronal development*
**作者**: Yao, M. et al.
**摘要**: 利用PAIP2磷酸化特异性抗体，揭示其磷酸化修饰在神经元突触形成中的作用，敲低PAIP2导致小鼠模型突触蛋白合成障碍。
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**注**：以上文献为示例性质，实际引用时请通过PubMed或Google Scholar检索真实文献(关键词：PAIP2 antibody, PABP interaction, cancer, phosphorylation)。若需具体文章，可提供进一步检索协助。
**Background of PAIP2 Antibody**
PAIP2 (Poly(A)-Binding Protein-Interacting Protein 2) is a regulatory protein involved in post-transcriptional gene expression. It interacts with poly(A)-binding protein (PABP), a key player in mRNA stability and translation, to modulate its activity. PAIP2 exists in two isoforms, PAIP2A and PAIP2B, generated through alternative splicing. PAIP2A is predominantly cytoplasmic and acts as a translational repressor by competing with PAIP1 (a translational enhancer) for binding to PABP, thereby disrupting the closed-loop structure of mRNA required for efficient ribosome recruitment. PAIP2B, localized to the nucleus, may influence mRNA processing or export.
PAIP2 antibodies are essential tools for studying its expression, localization, and functional roles in cellular processes such as stress responses, cell cycle regulation, and viral infection. Dysregulation of PAIP2 has been linked to diseases, including cancer and neurological disorders. These antibodies enable detection via techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding research into mRNA translation control mechanisms. By targeting specific isoforms or conserved domains, PAIP2 antibodies help elucidate its dual regulatory functions in cytoplasmic translation suppression and potential nuclear roles, offering insights into its therapeutic potential.
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