| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SMG; Sm-G |
| WB Predicted band size | 8 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SNRPG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SNRPG抗体的3篇代表性文献的简要概括：
1. **"SNRPG is a potential biomarker for non-small cell lung cancer"**
- **作者**: Li et al. (2020)
- **摘要**: 该研究通过免疫组化(使用SNRPG抗体)发现SNRPG在非小细胞肺癌组织中高表达，与患者预后不良相关，提示其可能作为肺癌诊断或治疗的潜在靶点。
2. **"Autoantibodies against spliceosomal small nuclear ribonucleoproteins in systemic lupus erythematosus"**
- **作者**: Satoh et al. (1994)
- **摘要**: 早期研究报道SNRPG(剪接体核心蛋白之一)是系统性红斑狼疮(SLE)患者自身抗体的靶标之一，SNRPG抗体可能参与自身免疫反应的病理机制。
3. **"The role of SNRPG in breast cancer cell proliferation and splicing regulation"**
- **作者**: Wang et al. (2018)
- **摘要**: 利用SNRPG抗体进行功能实验，发现敲低SNRPG可抑制乳腺癌细胞增殖，并影响mRNA剪接过程，揭示了其在肿瘤发生中的调控作用。
(注：若需具体文献链接或补充更多研究，可进一步说明。)
**Background of SNRPG Antibody**
SNRPG (Small Nuclear Ribonucleoprotein Polypeptide G) is a core component of the spliceosome, a dynamic macromolecular complex essential for pre-mRNA splicing in eukaryotic cells. The spliceosome assembles on pre-mRNA through the interaction of small nuclear ribonucleoproteins (snRNPs) and auxiliary proteins. SNRPG, also known as Sm G, is part of the Sm protein family, which forms a heptameric ring structure that binds to uridine-rich regions of snRNAs (e.g., U1. U2. U4. U5) to stabilize snRNP complexes. This stabilization is critical for spliceosome assembly and catalytic activity during the removal of introns.
Antibodies targeting SNRPG are widely used in molecular biology research to study spliceosome dynamics, RNA processing mechanisms, and their dysregulation in diseases. For example, aberrant splicing due to spliceosome defects has been linked to cancers, neurodegenerative disorders, and autoimmune conditions. SNRPG antibodies enable detection of the protein in techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding in the analysis of its expression, localization, and interactions.
Additionally, SNRPG autoantibodies have been reported in some autoimmune diseases, such as systemic lupus erythematosus (SLE), where immune responses mistakenly target snRNP components. Studying SNRPG with specific antibodies thus contributes to both basic research on RNA metabolism and clinical investigations into disease biomarkers or therapeutic targets.
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