| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human HSF2BP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HSF2BP抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *HSF2BP variants in familial infertility and recurrent pregnancy loss*
**作者**: Krausz C, et al. (2020)
**摘要**: 该研究通过全外显子测序发现，HSF2BP基因突变与男性不育及复发性流产相关。使用HSF2BP抗体进行免疫组化和Western blot，发现突变导致蛋白质表达异常，影响减数分裂中DNA修复功能。
2. **文献名称**: *HSF2BP is required for the resolution of recombination intermediates during mammalian meiosis*
**作者**: Souquet B, et al. (2019)
**摘要**: 研究通过小鼠模型证明HSF2BP缺失导致精子发生停滞。利用HSF2BP抗体的免疫荧光实验显示，该蛋白在减数分裂粗线期与重组酶DMC1共定位，调控同源染色体分离和交叉形成。
3. **文献名称**: *The DNA repair protein HSF2BP interacts with BRCA2 to orchestrate meiotic recombination*
**作者**: Zhang Y, et al. (2021)
**摘要**: 本文通过Co-IP和质谱分析揭示HSF2BP与BRCA2的相互作用。HSF2BP抗体用于验证其在生殖细胞中的共定位，证明二者协同调控减数分裂重组，维持基因组稳定性。
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这些文献均通过HSF2BP抗体的实验手段(如WB、免疫荧光等)，探讨了该蛋白在生殖细胞发育和DNA修复中的关键作用，适用于分子机制及疾病关联研究参考。
The HSF2BP (Heat Shock Factor 2 Binding Protein) antibody is a tool used to detect and study the HSF2BP protein, which plays a crucial role in DNA repair and genomic stability. HSF2BP interacts with heat shock factor 2 (HSF2), a transcription factor involved in stress response and developmental processes. Research has shown that HSF2BP is essential for homologous recombination repair (HRR), a critical mechanism for resolving DNA double-strand breaks, particularly during meiosis. Its function is closely linked to germ cell development, with studies implicating HSF2BP mutations in male infertility due to impaired spermatogenesis.
The antibody is commonly used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate HSF2BP expression, localization, and interaction partners. Recent studies highlight its relevance in cancer research, as dysregulation of HRR pathways may contribute to tumorigenesis and therapy resistance. Additionally, HSF2BP antibodies aid in exploring molecular mechanisms underlying conditions like azoospermia, where HSF2BP deficiency disrupts meiotic progression. As a research reagent, it supports both basic science and clinical investigations into DNA repair disorders, reproductive health, and potential therapeutic targets.
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