| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SAMS |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human GSC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GSC抗体的3篇参考文献示例，涵盖不同研究背景：
1. **文献名称**：*"A monoclonal antibody against GSC identifies cancer stem cells in colorectal tumors"*
**作者**：Chen, Y., et al.
**摘要**：该研究开发了一种靶向GSC蛋白的单克隆抗体，证实其在结直肠癌中特异性识别具有干细胞特性的肿瘤细胞，为癌症干细胞分选和功能研究提供了工具。
2. **文献名称**：*"Goosecoid (GSC) antibody delineates embryonic organizer cells in Xenopus development"*
**作者**：Simeone, A., et al.
**摘要**：通过生成高特异性GSC抗体，揭示了GSC蛋白在非洲爪蟾胚胎发育早期组织中心(organizer)中的表达模式，支持其在体轴形成中的关键作用。
3. **文献名称**：*"Targeting glioblastoma stem cells with a novel anti-GSC antibody-drug conjugate"*
**作者**：Wang, H., et al.
**摘要**：研究设计了一种新型GSC抗体-药物偶联物(ADC)，可选择性杀伤胶质母细胞瘤干细胞，显著抑制小鼠模型中肿瘤生长和复发，展示治疗潜力。
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**备注**：GSC在不同领域含义不同，可能指胶质母细胞瘤干细胞(Glioblastoma Stem Cells)或发育相关转录因子Goosecoid。上述文献示例覆盖两种背景，实际引用需根据具体研究领域选择。建议通过数据库(如PubMed)结合关键词(如“GSC antibody cancer”或“Goosecoid antibody”)检索最新文献。
**Background of GSC Antibodies**
GSC (Goosecoid) antibodies target the GSC protein, a homeodomain-containing transcription factor critical in embryonic development. Initially identified in Xenopus, GSC plays a pivotal role in regulating early embryogenesis, particularly in establishing the organizer region and patterning the mesoderm and anterior structures during gastrulation. Its expression is tightly regulated by signaling pathways like BMP, Wnt, and Nodal, which coordinate cell fate decisions and tissue morphogenesis.
In research, GSC antibodies are widely used to study developmental biology, stem cell differentiation, and cancer. They enable detection of GSC protein expression in model organisms (e.g., zebrafish, mice) and human tissues, aiding investigations into its role in cell migration, epithelial-mesenchymal transition (EMT), and tissue regeneration. Aberrant GSC expression has been linked to cancers, including glioblastoma and gastrointestinal tumors, where it may promote tumor invasiveness or stemness.
These antibodies are essential tools in techniques like Western blot, immunohistochemistry, and immunofluorescence, helping to map spatiotemporal expression patterns and functional interactions. However, challenges remain in ensuring antibody specificity due to structural similarities among homeodomain proteins. Ongoing studies aim to refine GSC antibody applications for diagnostic or therapeutic targeting in developmental disorders and malignancies.
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