| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | KA2; EAA2; GRIK2; GluK5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GRIK5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是基于GRIK5相关研究的示例参考文献格式(注：以下内容为模拟生成，实际文献需通过学术数据库检索)：
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1. **文献名称**: *GRIK5 receptor expression in Alzheimer's disease and its interaction with amyloid-beta*
**作者**: Smith A, et al.
**摘要**: 研究通过免疫组化和Western blot分析GRIK5蛋白在阿尔茨海默病患者脑组织中的表达变化，发现其与淀粉样斑块沉积相关，提示GRIK5可能参与神经退行性病理过程。
2. **文献名称**: *Development of a monoclonal antibody targeting the extracellular domain of GRIK5 for glioblastoma imaging*
**作者**: Chen L, et al.
**摘要**: 开发了一种高特异性抗GRIK5单克隆抗体，验证其在胶质母细胞瘤细胞系和小鼠模型中的靶向结合能力，为肿瘤诊断提供潜在工具。
3. **文献名称**: *Genetic and functional analysis of GRIK5 variants in schizophrenia*
**作者**: Patel R, et al.
**摘要**: 结合基因测序和免疫荧光技术，发现精神分裂症患者中GRIK5基因变异导致受体蛋白表达异常，抗体标记显示突触定位改变可能与疾病相关。
4. **文献名称**: *GRIK5 antibody-based ELISA for detecting autoimmune encephalitis biomarkers*
**作者**: Kim H, et al.
**摘要**: 建立了一种基于抗GRIK5抗体的ELISA检测方法，用于自身免疫性脑炎患者血清中自身抗体的快速筛查，具有较高敏感性和特异性。
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**实际文献检索建议**：
- 使用PubMed、Google Scholar等平台，以关键词 **"GRIK5 antibody"、"anti-GRIK5"、"GRIK5 receptor"** 结合研究领域(如神经疾病、癌症等)进行搜索。
- 关注抗体应用方向(如Western blot、IHC、诊断试剂开发)或疾病机制研究的相关论文。
The GRIK5 antibody is a crucial tool for studying the glutamate receptor ionotropic kainate type subunit 5 (GRIK5), also known as GluK5. which is a key component of kainate receptors—a subclass of ionotropic glutamate receptors (iGluRs). These receptors mediate excitatory neurotransmission in the central nervous system. GRIK5. encoded by the GRIK5 gene, forms heteromeric complexes with other kainate receptor subunits (e.g., GluK1-4) to regulate neuronal excitability, synaptic plasticity, and signal transduction. Unlike AMPA and NMDA receptors, kainate receptors, including those containing GRIK5. modulate both presynaptic neurotransmitter release and postsynaptic responses, influencing cognitive functions, learning, and memory.
GRIK5 antibodies are widely used in research to detect and localize the GRIK5 protein in tissues or cell lines via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of GRIK5 has been implicated in neurological and psychiatric disorders, such as Alzheimer's disease, epilepsy, and schizophrenia, as well as certain cancers. Studies using GRIK5 antibodies have revealed its role in synaptic pathology, neuronal hyperexcitability, and disease mechanisms, making it a potential therapeutic target. These antibodies also aid in exploring GRIK5's expression patterns, post-translational modifications, and interactions with other proteins, advancing our understanding of glutamate signaling in health and disease.
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