| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PH2; GLXR; GLYD |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human GRHPR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GRHPR抗体的3篇文献示例(内容为模拟概括，仅供参考)：
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1. **文献名称**: *Immunohistochemical localization of GRHPR in human tissues: implications for primary hyperoxaluria type 2*
**作者**: Rumsby, G., et al.
**摘要**: 研究通过特异性GRHPR抗体检测该酶在肝、肾等组织中的表达分布，证实其在草酸代谢中的关键作用，并揭示PH2(原发性高草酸尿症2型)患者中因基因突变导致的酶表达缺失。
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2. **文献名称**: *Development of a monoclonal antibody against human GRHPR for diagnostic applications*
**作者**: Coulter-Mackie, M., & Lannergren, K.
**摘要**: 报道一种高灵敏度的单克隆抗体制备，用于Western blot和ELISA检测，可有效区分健康个体与PH2患者的GRHPR蛋白水平，为临床诊断提供可靠工具。
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3. **文献名称**: *Comparative analysis of GRHPR antibody specificity across species*
**作者**: Williams, E., et al.
**摘要**: 评估不同物种(人、小鼠、大鼠)中GRHPR抗体的交叉反应性，发现部分抗体在非人样本中存在假阳性，强调抗体特异性验证对代谢疾病研究的重要性。
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如需具体文献，建议通过PubMed或Google Scholar以“GRHPR antibody”“primary hyperoxaluria”“glyoxylate reductase”为关键词检索近年研究。
The GRHPR (glyoxylate reductase/hydroxypyruvate reductase) antibody is a tool used to detect the GRHPR enzyme, a key metabolic protein involved in the glyoxylate and hydroxypyruvate pathways. GRHPR primarily catalyzes the reduction of glyoxylate to glycolate and hydroxypyruvate to D-glycerate, critical steps in preventing oxalate overproduction. Dysfunction of GRHPR due to genetic mutations is linked to primary hyperoxaluria type 2 (PH2), a rare autosomal recessive disorder characterized by excessive oxalate accumulation, nephrolithiasis, and renal failure.
Antibodies targeting GRHPR are essential for studying its expression, localization, and functional deficiencies in research and diagnostics. They are widely used in techniques like immunohistochemistry (IHC), Western blotting, and ELISA to assess GRHPR levels in tissues or cell lines, aiding in the confirmation of PH2 diagnoses. Commercial GRHPR antibodies are typically raised in model organisms (e.g., rabbits, mice) against specific epitopes of the human GRHPR protein, validated for specificity and sensitivity.
Recent studies also explore GRHPR's role beyond PH2. including its potential involvement in cancer metabolism and mitochondrial function. Reliable GRHPR antibodies thus support both clinical investigations and experimental research, bridging gaps in understanding metabolic disorders and therapeutic targeting.
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