| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LDHM; GSD11; PIG19; HEL-S-133P |
| WB Predicted band size | 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human LDHA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于LDHA抗体的3篇示例参考文献(文献为虚构示例，仅作格式参考)：
---
1. **文献名称**: *LDHA overexpression correlates with poor prognosis in colorectal cancer: an immunohistochemical study*
**作者**: Zhang Y., Li X., Wang H. et al.
**摘要**: 本研究通过免疫组化技术分析LDHA在结直肠癌组织中的表达水平，发现LDHA在肿瘤细胞中显著高表达，且与患者的总生存期缩短和转移风险增加相关，提示LDHA可作为潜在的预后生物标志物。
2. **文献名称**: *Targeting LDHA with a monoclonal antibody inhibits glycolysis and suppresses tumor growth in pancreatic cancer models*
**作者**: Smith R.L., Brown K.T., Garcia M. et al.
**摘要**: 开发了一种靶向LDHA的单克隆抗体，并在胰腺癌小鼠模型中验证其疗效。结果显示，该抗体通过抑制糖酵解通路减少乳酸生成，显著抑制肿瘤生长，为LDHA靶向治疗提供了实验依据。
3. **文献名称**: *LDHA-mediated metabolic reprogramming in tumor-associated macrophages promotes immunosuppression*
**作者**: Chen L., Wei F., Patel N. et al.
**摘要**: 研究利用LDHA抗体阻断肿瘤相关巨噬细胞(TAMs)中的LDHA活性，发现其可逆转TAMs的免疫抑制表型，增强T细胞抗肿瘤反应，揭示了LDHA在肿瘤微环境代谢调控中的关键作用。
---
**注**：以上文献为模拟示例，实际研究中请通过PubMed、Web of Science等数据库检索真实文献。
LDHA (Lactate Dehydrogenase A) is a critical enzyme in the glycolytic pathway, catalyzing the conversion of pyruvate to lactate under anaerobic conditions. It plays a pivotal role in cellular energy metabolism, particularly in cancer cells that rely on the Warburg effect—a metabolic shift favoring glycolysis even in the presence of oxygen. Overexpression of LDHA is associated with tumor progression, metastasis, and poor prognosis, making it a potential therapeutic target and biomarker in oncology.
LDHA antibodies are immunological tools designed to detect and quantify LDHA protein levels in various biological samples. They are widely used in research applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA to study LDHA expression patterns in cancer, metabolic disorders, and other diseases. These antibodies aid in elucidating LDHA's role in cellular metabolism, hypoxia response, and drug resistance mechanisms.
Commercially available LDHA antibodies are typically validated for specificity and sensitivity across species (e.g., human, mouse, rat) and sample types. Their development has accelerated studies exploring LDHA inhibition as a cancer treatment strategy and its involvement in non-oncological conditions like sepsis or neurodegenerative diseases. Proper validation, including knockout controls, is essential to ensure antibody reliability in experimental settings.
×
