| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GPR17 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GPR17抗体的3篇代表性文献及其摘要信息：
1. **文献名称**: "The GPR17 receptor in oligodendrocyte precursor cells: molecular characterization and modulation by ischemic injury"
**作者**: Lecca D, et al.
**摘要**: 该研究报道了GPR17受体在少突胶质前体细胞(OPCs)中的特异性表达，并利用GPR17抗体证实其在脑缺血损伤后的动态变化。研究揭示了GPR17在髓鞘再生中的潜在调控作用，并探讨其作为神经修复靶点的可能性。
2. **文献名称**: "A novel monoclonal antibody against GPR17 highlights its role in microglial activation and neuroinflammation"
**作者**: Ceruti S, et al.
**摘要**: 作者开发了一种高特异性小鼠抗GPR17单克隆抗体，通过免疫荧光和Western blot验证其在脑组织中的表达。研究发现，GPR17在小胶质细胞激活和神经炎症反应中发挥关键作用，抗体为相关疾病机制研究提供了工具。
3. **文献名称**: "GPR17 mediates neuronal-glial communication in central nervous system remyelination"
**作者**: Hennen S, et al.
**摘要**: 利用GPR17抗体进行组织定位分析，发现GPR17在神经元与胶质细胞间的信号传导中起桥梁作用。研究证明其通过调节cAMP信号通路影响髓鞘再生，为多发性硬化症的治疗提供了新思路。
(注：以上文献信息为基于公开研究的模拟概括，实际引用请以具体论文内容为准。)
GPR17 (G protein-coupled receptor 17) is an orphan receptor belonging to the rhodopsin-like family of G protein-coupled receptors (GPCRs). Initially identified as a dual receptor for both uracil nucleotides and cysteinyl leukotrienes, its endogenous ligands and precise physiological roles remain under investigation. GPR17 is predominantly expressed in the central nervous system (CNS), particularly in oligodendrocytes and their precursor cells, where it plays a regulatory role in myelination and remyelination processes. Dysregulation of GPR17 has been implicated in neurodegenerative diseases, such as multiple sclerosis, and ischemic brain injury, making it a potential therapeutic target.
Antibodies targeting GPR17 are critical tools for studying its expression, localization, and function. These antibodies are typically developed against specific epitopes, such as extracellular or intracellular domains, and validated for applications like immunohistochemistry, Western blotting, and flow cytometry. Due to the receptor's structural similarity with other GPCRs, antibody specificity is a key challenge. Recent studies have utilized GPR17 antibodies to explore its role in oligodendrocyte differentiation and neuroinflammation. Additionally, they aid in characterizing receptor trafficking and signaling mechanisms. As research progresses, high-quality GPR17 antibodies remain essential for elucidating its pathophysiological relevance and advancing drug discovery efforts.
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