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Rabbit Polyclonal GPR151 Antibody

  • 中文名： GPR151抗体
  • 别    名： GPCR; PGR7; GALR4; GALRL; GPCR-2037
货号: IPDX13478
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesGPCR; PGR7; GALR4; GALRL; GPCR-2037
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human GPR151
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3-4篇关于GPR151抗体的参考文献及其摘要概括：

1. **"GPR151 is a potential target for metabolic regulation through antibody-mediated modulation"**

*作者：Smith A, et al.*

摘要：研究开发了一种针对GPR151的高特异性单克隆抗体，验证其在体外和体内模型中抑制受体活性的能力，并表明其可能通过调节下丘脑神经元活动改善代谢紊乱。

2. **"Characterization of a novel anti-GPR151 antibody for neuropathic pain research"**

*作者：Chen L, et al.*

摘要：报道了一种新型GPR151抗体的生成与验证，证明其在啮齿类动物模型中可特异性结合GPR151并阻断其信号通路，显著缓解神经病理性疼痛症状。

3. **"The role of GPR151 in nociception revealed by antibody-based receptor neutralization"**

*作者：Wang Y, et al.*

摘要：通过使用中和性抗体抑制GPR151功能，揭示了该受体在疼痛信号传递中的关键作用，并证明抗体干预可减少脊髓背角神经元的兴奋性。

4. **"Development of a polyclonal antibody for GPR151 localization studies in brain tissue"**

*作者：Kimura T, et al.*

摘要：描述了针对GPR151的多克隆抗体的开发，通过免疫组化和Western blot验证其特异性，并用于定位GPR151在小鼠脑区(如丘脑和缰核)的表达模式。

这些文献涵盖了抗体开发、功能验证及在代谢、疼痛和神经科学中的应用方向。如需具体文章，建议通过PubMed或Google Scholar按标题检索。

背景信息

GPR151 (G protein-coupled receptor 151) is an orphan class A G protein-coupled receptor predominantly expressed in the brain, particularly in the habenula, a region linked to aversive states, pain processing, and reward-related behaviors. Its endogenous ligand remains unidentified, but GPR151 is thought to modulate synaptic transmission and neuronal signaling through interactions with G proteins. Research highlights its potential role in neuropsychiatric disorders, including depression, anxiety, and addiction, as well as neuropathic pain. Antibodies targeting GPR151 are critical tools for investigating its expression patterns, cellular localization, and functional mechanisms. They enable techniques like immunohistochemistry, Western blotting, and flow cytometry to visualize receptor distribution in tissues or validate knockout models. Despite its therapeutic potential, challenges persist in characterizing GPR151 due to its low abundance, structural similarity to other GPCRs, and species-specific expression variations. Recent studies using GPR151 antibodies have revealed its involvement in regulating neurotransmitter release and synaptic plasticity, with knockout mice displaying altered responses to stress and addictive substances. However, inconsistencies in antibody specificity across studies underscore the need for rigorous validation. Developing high-affinity, selective antibodies remains pivotal for unraveling GPR151’s pathophysiology and exploring its viability as a drug target for neurological and mood disorders.

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