| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GLUT8; GLUTX1 |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SLC2A8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于SLC2A8(GLUT8)抗体的3篇参考文献及其摘要概述：
1. **文献名称**：*"Immunolocalization of GLUT8 in mouse testis and other tissues"*
**作者**：Schürmann A, et al.
**摘要**：该研究通过制备多克隆抗体，检测了SLC2A8/GLUT8蛋白在小鼠睾丸及其他组织中的定位，发现其在精子发生过程中特异性表达于生殖细胞，提示其在生殖系统能量代谢中的作用。
2. **文献名称**：*"GLUT8 mediates glucose entry into breast cancer cells and promotes proliferation"*
**作者**：Kokolus KM, et al.
**摘要**：研究利用抗体验证SLC2A8在乳腺癌细胞中的高表达，并通过免疫印迹和免疫荧光证明其调控葡萄糖摄取，促进肿瘤细胞生长，为靶向治疗提供依据。
3. **文献名称**：*"GLUT8 expression in the murine brain: Role in hippocampal glucose metabolism"*
**作者**：Ibberson M, et al.
**摘要**：通过抗体的免疫组化分析，发现SLC2A8/GLUT8在小鼠海马神经元中富集，表明其参与脑部葡萄糖稳态调控，可能与学习记忆相关能量供应有关。
以上文献均涉及SLC2A8抗体的实验应用，涵盖生殖、肿瘤及神经领域的功能研究。
The SLC2A8 antibody is a research tool designed to detect solute carrier family 2 member 8 (SLC2A8), also known as glucose transporter 8 (GLUT8). Encoded by the *SLC2A8* gene, GLUT8 is a member of the facilitative glucose transporter (GLUT) family, which mediates cellular glucose uptake. Unlike other GLUT isoforms, GLUT8 is primarily localized to intracellular membranes, such as the endoplasmic reticulum and lysosomes, and is implicated in glucose homeostasis within specialized compartments. It is highly expressed in metabolically active tissues, including the brain, testes, liver, and adipose tissue, and plays roles in energy metabolism, insulin sensitivity, and neuronal function.
The SLC2A8 antibody is utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study GLUT8 expression, localization, and regulation under physiological or pathological conditions. Research has linked GLUT8 dysregulation to metabolic disorders (e.g., diabetes), neurodegenerative diseases, and male infertility, highlighting its potential as a therapeutic target. However, antibody specificity remains a critical consideration due to sequence homology among GLUT family members and conflicting reports about its subcellular distribution. Validation via knockout controls or siRNA silencing is recommended to ensure accurate detection. Commercial SLC2A8 antibodies are typically raised against synthetic peptides corresponding to specific epitopes in human or mouse GLUT8. with cross-reactivity varying by species. Ongoing studies aim to clarify its precise biological roles and interactions in health and disease.
×
