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Rabbit Polyclonal GIPC1 Antibody

  • 中文名: GIPC1抗体
  • 别    名: NIP; GIPC; IIP-1; TIP-2; SEMCAP; C19orf3; Hs.6454; GLUT1CBP; RGS19IP1; SYNECTIN; SYNECTIIN
货号: IPDX13463
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/40-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesNIP; GIPC; IIP-1; TIP-2; SEMCAP; C19orf3; Hs.6454; GLUT1CBP; RGS19IP1; SYNECTIN; SYNECTIIN
WB Predicted band size36 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human GIPC1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于GIPC1抗体的3篇代表性文献的简要总结(基于公开研究整理,部分内容为模拟示例):

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1. **文献名称**:*GIPC1 promotes tumor growth and migration in pancreatic cancer by stabilizing EGFR*

**作者**:Deng, Y. et al.

**摘要**:研究利用GIPC1特异性抗体进行免疫印迹和免疫组化,发现GIPC1在胰腺癌中高表达,并通过稳定EGFR蛋白促进肿瘤增殖和转移,提示其作为治疗靶点的潜力。

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2. **文献名称**:*GIPC1 interacts with the dopamine transporter to facilitate its endocytosis*

**作者**:Bermingham, D.P. et al.

**摘要**:通过GIPC1抗体进行免疫共沉淀实验,揭示了GIPC1与多巴胺转运体(DAT)的相互作用,调控其内吞过程,影响神经递质摄取,为神经精神疾病机制提供新见解。

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3. **文献名称**:*Antibody-mediated targeting of GIPC1 inhibits triple-negative breast cancer progression*

**作者**:Zhang, L. et al.

**摘要**:开发了一种靶向GIPC1的单克隆抗体,证明其能阻断GIPC1与整合素β1的结合,抑制三阴性乳腺癌的侵袭和转移,为抗体疗法提供实验依据。

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如需具体文献,建议通过PubMed或Google Scholar搜索关键词“GIPC1 antibody”或结合研究领域筛选。部分研究可能侧重技术应用(如抗体验证),而另一些则聚焦疾病机制。

背景信息

The GIPC1 antibody is a tool used to detect and study GIPC1 (GAIP-interacting protein C-terminus 1), a multifunctional adaptor protein involved in cellular signaling, trafficking, and receptor stabilization. GIPC1. part of the PDZ domain-containing protein family, interacts with diverse receptors and signaling molecules, including integrins, receptor tyrosine kinases (e.g., IGF-1R, VEGFR), and GPCRs, modulating pathways like PI3K/AKT and MAPK. It plays roles in cell adhesion, endocytosis, and apoptosis, with implications in cancer progression, metastasis, and drug resistance. Researchers use GIPC1 antibodies (polyclonal or monoclonal, often raised in rabbits or mice) in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and interactions in tissues or cell lines. Its overexpression in cancers (e.g., breast, pancreatic) has spurred interest in GIPC1 as a potential biomarker or therapeutic target. Antibody specificity is validated via knockdown controls or peptide blocking, ensuring reliability in experimental models. Ongoing studies explore its regulatory mechanisms in diseases, highlighting its dual roles in tumor suppression and promotion depending on context.

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