| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MOB1D; C9orf35; MOBKL2B |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human MOB3B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MOB3B抗体的3篇示例文献(注：内容为虚构，仅作参考格式示例)：
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1. **文献名称**: *MOB3B Antibody Development and Its Role in Hippo Signaling*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种针对MOB3B蛋白的高特异性多克隆抗体，通过Western blot和免疫荧光验证其在多种细胞系中的检测效果。研究发现MOB3B通过调控Hippo通路中的LATS激酶活性，影响细胞增殖和凋亡。
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2. **文献名称**: *MOB3B Expression in Cancer: A Monoclonal Antibody-Based Study*
**作者**: Zhang L, et al.
**摘要**: 作者利用自主研发的小鼠抗MOB3B单克隆抗体，分析了其在乳腺癌组织中的表达模式。结果显示，MOB3B高表达与患者不良预后相关，提示其可能作为潜在肿瘤标志物。
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3. **文献名称**: *Functional Characterization of MOB3B in Mitotic Progression*
**作者**: Lee JH, et al.
**摘要**: 通过特异性抗体敲低和免疫共沉淀实验，本研究发现MOB3B与有丝分裂相关蛋白复合物相互作用，参与调控纺锤体组装检查点，影响细胞周期进程。
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**备注**：以上文献为模拟示例，实际研究中请通过PubMed或Web of Science等数据库检索真实发表的论文。
MOB3B (Mps One Binder kinase activator-like 3B) is a member of the MOB (Mps One Binder) protein family, which plays critical roles in cell cycle regulation, signaling pathways, and organ development. MOB proteins are evolutionarily conserved and primarily function as coactivators or coregulators of kinases. MOB3B, specifically, shares structural homology with other MOB family members, including a conserved N-terminal domain, but exhibits distinct functional characteristics. Unlike MOB1A/B, which are central to the Hippo tumor suppressor pathway through interactions with LATS1/2 kinases, MOB3B does not directly engage with Hippo core components. Instead, it has been implicated in modulating non-canonical signaling networks, potentially influencing cell proliferation and apoptosis.
Research suggests MOB3B interacts with protein kinases such as STK24/25 (related to Germinal Center Kinases), though its precise mechanistic role remains less defined compared to other MOB proteins. MOB3B expression is detected in various tissues, with dysregulation observed in cancers and neurological disorders, hinting at its pathological relevance. Antibodies targeting MOB3B are essential tools for studying its localization, expression patterns, and molecular interactions. These antibodies (polyclonal or monoclonal) are typically validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also explore MOB3B's phosphorylation-dependent interactions and its potential crosstalk with other signaling cascades, underscoring its emerging role in cellular homeostasis and disease.
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